Discharge of frontal eye field neurons during saccadic and following eye movements in unanesthetized monkeys
Discharge of frontal eye field neurons during saccadic and following eye movements in unanesthetized monkeys
复制标题
未麻醉猴子扫视和眼球运动后额部眼区神经元的放电
作者：
E. Bizzi
本研究通过记录未麻醉的猴子在头部受限的情况下坐在灵长类椅子上的额叶眼野（FEF）的单细胞活动来研究眼动控制的皮层机制。发现了两种类型的细胞（I和II），I型神经元在向给定方向的随意扫视和眼球震颤的快速相期间放电。这种类型的细胞在缓慢的追踪运动中保持沉默。当眼睛朝向特定方向时，II型细胞显示出稳定的放电。这些细胞在平稳的追踪运动和眼球震颤的缓慢阶段也会放电，前提是眼睛移动的位置与眼睛停在那里时的神经元活动有关。通过刺激大脑脚的逆向反应，鉴定出所有的II型神经元和少数的I型神经元。这些结果表明，皮层神经元的放电模式明显相关的扫视或追求运动，这两种不同类型的眼球运动是由不同的神经元机制产生的观点。
SummaryThe cortical mechanism of eye-movement control was investigated by recording single cell activity from the frontal eye field (FEF) in unanesthetized monkeys seated in a primate chair with head restrained. Two types of cells (I and II) were found. Type I neurons fired during voluntary saccades occurring in a given direction and during the fast phase of nystagmus. Cells of this type were silent during slow pursuit movement. Type II cells showed steady discharge when the eyes were oriented in a specific direction. These cells discharged also during smooth pursuit movements and the slow phase of nystagmus, provided that the eyes were moving across positions which would have been associated with neuronal activity had the eyes come to rest there. All of Type II and a few of Type I neurons were identified by antidromic response to stimulation of the cerebral peduncle. These results indicate that cortical neurons have patterns of discharge distinctly related either to saccadic or to pursuit movements, in line with the view that these two different types of eye movement are generated by distinct neuronal mechanisms.