TAIL PINCH-INDUCED CHANGES IN THE TURNOVER AND RELEASE OF DOPAMINE AND 5-HYDROXYTRYPTAMINE IN DIFFERENT BRAIN-REGIONS OF THE RAT
TAIL PINCH-INDUCED CHANGES IN THE TURNOVER AND RELEASE OF DOPAMINE AND 5-HYDROXYTRYPTAMINE IN DIFFERENT BRAIN-REGIONS OF THE RAT
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DOI：
10.1016/0306-4522(90)90127-p
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发表时间：
1990-01-01
期刊：
影响因子：
3.3
通讯作者：
FILLENZ, M
中科院分区：
文献类型：
--
作者：
PEI, Q;ZETTERSTROM, T;FILLENZ, M
通过附在大鼠尾巴上的回形针进行尾部捏捏。代谢物/递质比率的离体变化被用作多巴胺和5-羟色胺周转变化的测量。 2分钟尾夹后，纹状体中的多巴胺周转率增加，但额叶皮层、下丘脑或嗅结节中的多巴胺周转率没有增加：额叶皮层和海马中的5-羟色胺周转率增加，而纹状体、下丘脑和嗅结节中的5-羟色胺周转率没有变化。使用微透析来监测夹尾期间和之后细胞外神经递质和代谢物浓度的变化。捏尾 5 分钟会导致纹状体中的多巴胺和海马中的 5-羟色胺迅速升高。 5-羟色胺代谢物 5-羟基吲哚乙酸增加较小，多巴胺代谢物 3,4-二羟基苯乙酸仅增加不显着。
Tail pinch was administered through a paper clip attached to the rat''s tail. The ex vivo changes in the metabolite/transmitter ratio were used as a measure of changes in the turnover of dopamine and 5-hydroxytryptamine. After a 2-min tail pince dopamine turnover was increased in the striatum but not in the frontal cortex, hypothalamus or olfactory tubercle: 5-hydroxytryptamine turnover was increased in frontal cortex and hippocampus and was unchanged in striatum, hypothalamus and olfactory tubercle. Microdialysis was used to monitor the changes in extracellular neurotransmitter and metabolite concentrations during and after tail pinch. A 5-min tail pinch caused a rapid rise of both dopamine in the striatum and 5-hydroxytryptamine in the hippocampus. There was a smaller increase in the 5-hydroxytryptamine metabolite 5-hydroxyindoleacetic acid and only a non-significant increase in the dopamine metabolite 3,4-dihydroxyphenylacetic acid.