Angucyclinones from an Indonesian Streptomyces sp.
Angucyclinones from an Indonesian Streptomyces sp.
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DOI：
10.1021/np0704102
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发表时间：
2008-01-01
影响因子：
5.1
通讯作者：
Proteau, Philip. J.
中科院分区：
文献类型：
--
作者：
Fotso, Serge;Mahmud, Taifo;Proteau, Philip. J.
从印度尼西亚链霉菌 ICBB8230 菌株提取物的生物测定引导分馏中分离出六种新的安古环酮聚酮化合物，命名为泛霉素 A-F，以及三种已知代谢物 (+)-福建霉素 A、(+)-ochromycinone 和 emycin C。这些新化合物是高氧安古环素，似乎是从奥铬霉素或福建霉素生物合成衍生的。它们的结构通过 X 射线晶体分析、一维和二维核磁共振谱的解释以及将数据与结构相关的已知天然产物的数据进行比较来确定。尽管与具有抗生素活性的安古环素类药物结构相似，但在针对多种细菌和真菌进行测试时，泛霉素并未表现出任何生长抑制作用。
Six new angucyclinone polyketides named panglimycins A-F were isolated together with the three known metabolites (+)-fujianmycin A, (+)-ochromycinone, and emycin C from the bioassay-guided fractionation of the extract of the Indonesian Streptomyces strain ICBB8230. The new compounds are highly oxygenated angucyclinones that appear to be biosynthetically derived from ochromycinone or fujianmycin. Their structures were deter-mined by X-ray crystal analysis, interpretation of 1D- and 2D-NMR spectra, and comparison of the data with those of structurally related known natural products. Despite structural similarities to angucyclinones with antibiotic activities, the panglimycins did not exhibit any growth inhibition when tested against several bacteria and fungi.