The skeletal vascular system - Breathing life into bone tissue
The skeletal vascular system - Breathing life into bone tissue
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DOI：
10.1016/j.bone.2017.08.022
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发表时间：
2018-10-01
期刊：
影响因子：
4.1
通讯作者：
Carmeliet, Geert
中科院分区：
文献类型：
--
作者：
Stegen, Steve;Carmeliet, Geert
在骨骼发育、内环境稳定和修复过程中，致密的血管系统为高度合成代谢的骨骼细胞提供氧气和营养。骨中血管系统的特征是两个毛细血管系统的串联组织，每个毛细血管系统以特定的形态学和生理学特征为代表。特别是动脉毛细血管介导骨血管系统的生长，作为骨骼和造血祖细胞的生态位，并将血管生成与骨生成偶联。内皮细胞和骨祖细胞不仅在物理上相互作用，而且通过分泌生长因子相互交流。重要的血管生成生长因子是血管内皮生长因子，其在骨骼细胞中的表达受成骨转录因子和缺氧信号传导控制，而内皮细胞分泌血管分泌因子受Notch信号传导、血流和可能的缺氧调节。骨丢失和受损的骨折修复通常与血管网络减少和紊乱有关，血管生成反应的治疗靶向可能有助于增强骨再生。(C)2017爱思唯尔公司All rights reserved.
During bone development, homeostasis and repair, a dense vascular system provides oxygen and nutrients to highly anabolic skeletal cells. Characteristic for the vascular system in bone is the serial organization of two capillary systems, each typified by specific morphological and physiological features. Especially the arterial capillaries mediate the growth of the bone vascular system, serve as a niche for skeletal and hematopoietic progenitors and couple angiogenesis to osteogenesis. Endothelial cells and osteoprogenitor cells interact not only physically, but also communicate to each other by secretion of growth factors. A vital angiogenic growth factor is vascular endothelial growth factor and its expression in skeletal cells is controlled by osteogenic transcription factors and hypoxia signaling, whereas the secretion of angiocrine factors by endothelial cells is regulated by Notch signaling, blood flow and possibly hypoxia. Bone loss and impaired fracture repair are often associated with reduced and disorganized blood vessel network and therapeutic targeting of the angiogenic response may contribute to enhanced bone regeneration. (C) 2017 Elsevier Inc. All rights reserved.