DEVELOPMENT AND APPLICATION OF A CONTINUOUS MICROWAVE REACTOR FOR ORGANIC-SYNTHESIS
DEVELOPMENT AND APPLICATION OF A CONTINUOUS MICROWAVE REACTOR FOR ORGANIC-SYNTHESIS
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DOI：
10.1021/jo00091a033
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发表时间：
1994-06-17
影响因子：
3.6
通讯作者：
STRAUSS, CR
中科院分区：
文献类型：
--
作者：
CABLEWSKI, T;FAUX, AF;STRAUSS, CR
开发了实验室规模的连续微波反应器(CMR)，用于在压力高达1400kPa、温度高达200℃的各种溶剂中进行常规、快速和安全的有机合成。讨论了CMR的优点和应用，以及设计的基本原理。与CMR进行的反应包括亲核取代、加成、酯化、酯交换、缩醛、酰胺化、碱和酸催化的水解、异构化、脱羧基和消除。命名反应包括Michael加成反应、Hofmann降解反应、Williamson乙醚合成反应、Mannich反应、Finkelstein反应、Baylis-Hillman反应和Knovenagel反应。
A laboratory-scale continuous microwave reactor (CMR) has been developed and used to conduct organic syntheses routinely, rapidly, and safely in a range of solvents, under pressures up to 1400 kPa and at temperatures up to 200 degrees C. Advantages and applications of the CMR are discussed, along with the rationale for the design. Reactions carried out with the CMR included nucleophilic substitution, addition, esterification, transesterification, acetalization, amidation, base- and acid-catalyzed hydrolysis, isomerization, decarboxylation, and elimination. Name reactions included the Michael addition, Hofmann degradation, Williamson ether synthesis, and the Mannich, Finkelstein, Baylis-Hillman, and Knoevenagel reactions.