Interaction of naphthyl heterocycles with DNA: effects of thiono and thio groups
Interaction of naphthyl heterocycles with DNA: effects of thiono and thio groups
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DOI：
10.1039/a908787g
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发表时间：
2000
期刊：
影响因子：
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通讯作者：
X. Qian;Tian‐Bao Huang;D. Wei;Donghui Zhu;Zhu;Wei Yao
中科院分区：
文献类型：
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作者：
X. Qian;Tian‐Bao Huang;D. Wei;Donghui Zhu;Zhu;Wei Yao
与使用含氧对应物 (1) 相比，N-[β-(N',N'-二甲基氨基)乙基]二硫代-1,8-萘二甲酰亚胺 (2) 对 DNA 的嵌入和光裂解极其有效。推测它们在 366 nm 紫外光下的光裂解作用是通过电子从碱基转移到萘二甲酰亚胺的三重态来进行的。与含氧化合物相比，其他具有硫代或硫代基团的化合物也观察到 DNA 嵌入和 DNA 光裂解的增强。
The intercalation and photocleavage of DNA by N-[β-(N′,N′-dimethylamino)ethyl]dithiono-1,8-naphthalimide (2) were extremely effective compared to the use of the oxygen-containing counterpart (1). Their photocleavage action under 366 nm UV light is proposed to proceed by electron transfer from bases to the triplet state of the naphthalimides. The enhancement of the intercalation of DNA and the photocleavage of DNA were also observed for other compounds possessing a thiono or thio group compared with their oxygen-containing counterparts.