A Mild Glycosylation Protocol with Glycosyl 1-Methylimidazole-2-carboxylates as Donors
A Mild Glycosylation Protocol with Glycosyl 1-Methylimidazole-2-carboxylates as Donors
复制标题
以糖基 1-甲基咪唑-2-羧酸酯为供体的温和糖基化方案
DOI：
10.1002/ejoc.202100677
复制
发表时间：
2021-07-21
影响因子：
2.8
通讯作者：
Yu, Biao
中科院分区：
文献类型：
--
作者：
Chen, Jianpeng;Tang, Yu;Yu, Biao
通过使用糖基1-甲基咪唑-2-羧酸酯开发了温和的糖基化方案。这种糖基化可以通过一系列金属三氟甲磺酸盐和三氟甲酰胺，特别是Cu（OTf）（2）来促进。该反应是通过活化的糖基酯供体通过与金属阳离子的配位由相邻的1-甲基咪唑螯合基团的辅助。
A mild glycosylation protocol is developed by using glycosyl 1-methylimidazole-2-carboxylates. Such a glycosylation can be promoted by a series of metal triflates and triflimides, especially Cu(OTf)(2). The reaction is initiated by activation of the glycosyl ester donor via coordination with the metal cation assisted by the adjacent 1-methylimidazole chelating group.