THERMIC EFFECT OF GLUCOSE IN MAN - OBLIGATORY AND FACULTATIVE THERMOGENESIS
THERMIC EFFECT OF GLUCOSE IN MAN - OBLIGATORY AND FACULTATIVE THERMOGENESIS
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DOI：
10.1172/jci111573
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发表时间：
1984-01-01
影响因子：
15.9
通讯作者：
JEQUIER, E
中科院分区：
文献类型：
--
作者：
ACHESON, KJ;RAVUSSIN, E;JEQUIER, E
交感神经系统对静脉注射热效应的贡献。在正常血糖(90mg/dl)条件下，在2个高胰岛素血症水平(约90μU/ml和约620μU/ml)下，对10名健康年轻男性在用普萘洛尔阻断β-肾上腺素能受体之前和之后的葡萄糖和胰岛素进行了研究。在葡萄糖摄取的稳态条件下（0.515 .+-. 0.046 和 0.754 .+-. 0.056 g/min），能量消耗显着增加（分别为 0.10 .+-. 0.02 kcal/min，P < 0.001 和 0.21 .+-. 0.02 kcal/min，P < 0.01）。类似地，葡萄糖氧化从 0.100.+- 增加。 0.015 至 0.266.+-。 0.022 克/分钟 (P < 0.001) at .apprx. 90 .mu.U/ml 胰岛素和 0.082 .+- 起。 0.013 至 0.295.+-。 0.018 克/分钟 (P < 0.001) at .apprx. 620μU/ml胰岛素。同时，非氧化葡萄糖处置或葡萄糖储存的比率为0.249±。 0.033 和 0.459.+-。分别为 0.048 克/分钟。此时，输注葡萄糖/胰岛素的热效应为5.3±。 0.9 和 7.5.+-。 0.7%，葡萄糖储存的能量成本为0.50.+-。 0.16 kcal/g 和 0.47 .+-。 2 个不同葡萄糖摄取水平下为 0.04 kcal/g。用普萘洛尔阻断β-肾上腺素能受体后，两项研究中的葡萄糖摄取、氧化和储存均未改变，但观察到能量消耗显着降低(1.41.+-.0.06-1.36.+-.0.05 kcal/min，在约90.mu.U/ml胰岛素时P<0.01，和1.52.+-.0.05kcal/min，P<0.01。 0.07-1.43.+-. 0.05 kcal/min，P < 0.005 at .apprx。 620μU/ml胰岛素）导致输注葡萄糖/胰岛素的估计热效应和葡萄糖储存的能量成本显着下降。两项研究结果的回归分析表明，葡萄糖储存的平均能量成本为 0.36 kcal/g (r = 0.74，P < 0.001)，在用普萘洛尔阻断 β-肾上腺素能受体期间，该能量成本显着下降 (P < 0.005) 至 0.21 kcal/g (r = 0.49，P < 0.05)。后者与根据理论基础计算的葡萄糖储存为糖原的代谢成本（即强制性产热）非常一致。 β-肾上腺素能介导的交感神经活动几乎是健康人在正常血糖和高胰岛素血症条件下能量消耗超过处理和储存葡萄糖的必需需求的全部增加的原因。葡萄糖储存的能量消耗在正常（约90μU/ml）和超生理（约620μU/ml）血浆胰岛素浓度下没有不同。
The contribution of the sympathetic nervous system to the thermic effect of i.v. glucose and insulin was studied in 10 healthy young men before and after .beta.-adrenergic receptor blockade with propranolol during conditions of normoglycemia (90 mg/dl) at 2 levels of hyperinsulinemia (.apprx. 90 .mu.U/ml and .apprx. 620 .mu.U/ml). During steady state conditions of glucose uptake (0.515 .+-. 0.046 and 0.754 .+-. 0.056 g/min), significant increases were observed in energy expenditure (0.10 .+-. 0.02 kcal/min, P < 0.001 and 0.21 .+-. 0.02 kcal/min, P < 0.01, respectively). Similarly, glucose oxidation increased from 0.100 .+-. 0.015 to 0.266 .+-. 0.022 g/min (P < 0.001) at .apprx. 90 .mu.U/ml insulin and from 0.082 .+-. 0.013 to 0.295 .+-. 0.018 g/min (P < 0.001) at .apprx. 620 .mu.U/ml insulin. Concomitantly, the rate of nonoxidative glucose disposal or glucose storage was 0.249 .+-. 0.033 and 0.459 .+-. 0.048 g/min, respectively. At this time the thermic effect of infused glucose/insulin was 5.3 .+-. 0.9 and 7.5 .+-. 0.7%, and the energy cost of glucose storage was 0.50 .+-. 0.16 kcal/g and 0.47 .+-. 0.04 kcal/g at the 2 different levels of glucose uptake. After .beta.-adrenergic receptor blockade with propranolol, glucose uptake, oxidation and storage were unchanged in both studies, but significant decreases in energy expenditure were observed (1.41 .+-. 0.06-1.36 .+-. 0.05 kcal/min, P < 0.01 at .apprx. 90 .mu.U/ml insulin, and 1.52 .+-. 0.07-1.43 .+-. 0.05 kcal/min, P < 0.005 at .apprx. 620 .mu.U/ml insulin) causing significant falls in both the estimated thermic effect of infused glucose/insulin and the energy cost of glucose storage. Regression analysis of the results from both studies indicated a mean energy cost for glucose storage of 0.36 kcal/g (r = 0.74, P < 0.001), which fell significantly (P < 0.005) to 0.21 kcal/g (r = 0.49, P < 0.05) during .beta.-adrenergic receptor blockade with propranolol. The latter is in close agreement with that calculated on theoretical grounds for the metabolic cost of glucose storage as glycogen, i.e., obligatory thermogenesis. .beta.-adrenergically mediated sympathetic nervous activity is responsible for almost the entire rise in energy expenditure in excess of the obligatory requirements for processing and storing glucose during conditions of normoglycemia and hyperinsulinemia in healthy man. The energy cost of glucose storage is not different at normal (.apprx. 90 .mu.U/ml) and supraphysiological (.apprx. 620 .mu.U/ml) plasma insulin concentrations.