Effectiveness of a bioabsorbable conduit in the repair of peripheral nerve
Effectiveness of a bioabsorbable conduit in the repair of peripheral nerve
复制标题
DOI：
10.1016/0142-9612(96)84669-2
复制
发表时间：
1996-05-01
期刊：
影响因子：
14
通讯作者：
Giardino, R
中科院分区：
文献类型：
--
作者：
Aldini, NN;Perego, G;Giardino, R
用一种生物可吸收的共聚物--聚(L-丙交酯-6-己内酯)制成的新型导管，在动物模型中被评价为神经再生的指南。该管道内径1.3 mm，壁厚175µm，在Wistar大鼠坐骨神经横断的近端和远端之间插入长1.2 cm的节段，桥接1 cm的神经间隙。所有手术均在全身麻醉下使用显微外科技术完成。术后1、3、6个月进行对照，30d后导管仍未受损，90d、180d出现进行性降解征象，组织学和电子显微镜观察证实管腔内神经再生有效。这些初步结果强调了导管在实现神经假体方面的有趣特性。
A new conduit made with a bioabsorbable copolymer, poly(L-lactide-co-6-caprolactone), was evaluated in an animal model as a guide for nerve regeneration. The conduit had an inner diameter of 1.3 mm and a wall thickness of 175 mu m. Segments of length 1.2 cm were interposed between the proximal and distal stumps of transected ischiatic nerves in Wistar rats, bridging a nerve gap of 1 cm. All of the procedure was performed under general anaesthesia using microsurgical techniques. Controls were performed at 1, 3 and 6 months and it was demonstrated that the conduit was still undamaged after 30 d. Progressive signs of degradation appeared at 90 and 180 d. Nerve regeneration in the lumen was effective as confirmed by histological and electron microscopical investigations. These preliminary results emphasize the interesting properties of the conduit with regard to the achievement of a neural prosthesis.