The dual-specificity protein phosphatase Yvh1p acts upstream of the protein kinase Mck1p in promoting spore development in Saccharomyces cerevisiae
The dual-specificity protein phosphatase Yvh1p acts upstream of the protein kinase Mck1p in promoting spore development in Saccharomyces cerevisiae
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DOI：
10.1128/jb.181.17.5219-5224.1999
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发表时间：
1999-09-01
影响因子：
3.2
通讯作者：
Cooper, TG
中科院分区：
文献类型：
--
作者：
Beeser, AE;Cooper, TG
Diploid Saccharomyces cerevisiae cells induce YVH1 expression and enter the developmental pathway, leading to sporulation when starved for nitrogen. We show that yvh1 disruption causes a defect in spore maturation; overexpression of MCK1 or IME1 suppresses this yvh1 phenotype. While mck1 mutations are epistatic to those in yvh1 relative to spore maturation, overexpression of MCK1 does not suppress the yvh1 slow-vegetative-growth phenotype. We conclude that (i) Yvh1p. functions earlier than Mck1p and Ime1p in the signal transduction cascade that regulates sporulation and is triggered by nitrogen starvation and (ii) the role of Yvh1p in gametogenesis can be genetically distinguished from its role in vegetative growth.
