Relationship between skeinoid fibers and stromal matrix in gastrointestinal stromal tumors: Morphometric analysis with quick‐freezing and deep‐etching method
Relationship between skeinoid fibers and stromal matrix in gastrointestinal stromal tumors: Morphometric analysis with quick‐freezing and deep‐etching method
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胃肠道间质瘤中束状纤维与基质基质的关系：速冻深蚀法形态测量分析
DOI：
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
N. Nemoto
中科院分区：
文献类型：
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作者：
A. Hemmi;Y. Inaniwa;S. Ohno;Y. Fujii;N. Terada;M. Mitsumata;N. Nemoto
我们之前使用快速冷冻和深蚀刻方法对胃肠道自主神经肿瘤伴Skeinoid纤维（SF）进行的研究表明，肿瘤细胞周围预先存在的网状结构中一个根与相邻根之间的距离（DRNR）与SF的周期性一致。因此，测量DRNR的网络可以阐明SF的发展的细胞周围基质的意义。在本研究中，我们分析了3例胃肠道间质瘤（GIST）的网状结构，这3例GIST显示不同的免疫组化染色，但通过免疫组化和/或电子显微镜证实具有平滑肌分化（SMD）。3例GIST的DRNR呈相似的直方图模式（峰值20-30 nm，平均值28.02、25.74和26.45 nm），明显短于SF的周期（峰值40-45 nm，平均值42.14）。虽然我们需要进一步的研究与额外的GIST的情况下，我们推测，GIST与SMD的细胞周基质是不适合SF的发展。
Our previous study of a gastrointestinal autonomic nerve tumor with skeinoid fibers (SF) using the quick‐freezing and deep‐etching method, suggested that the distance between one radix and a neighboring radix (DRNR) in pre‐existing meshwork structures around the tumor cells is consistent with the periodicity of the SF. Therefore, measurement of the DRNR in the meshwork could clarify the significance of the pericellular matrix for SF development. In the present study, we analyzed the meshwork in three cases of gastrointestinal stromal tumor (GIST), which showed different immunohistochemical stainings, but confirmed to have smooth muscle differentiation (SMD) by immunohistochemistry and/or electron microscopy. The DRNR from the three cases of GIST showed similar histogram patterns (a peak of 20–30 nm, mean values of 28.02, 25.74 and 26.45 nm), which were significantly shorter than the periodicity of SF (a peak of 40–45 nm, mean value of 42.14). Although we need further studies with additional GIST cases, we speculate that the pericellular matrix of GIST with SMD is not suitable for SF development.
胃肠道自主神经（GAN）肿瘤。
影响因子：
4.6
作者：
Walker,P;Dvorak,AM
通讯作者：
Dvorak,AM