Growth charts for Down's syndrome from birth to 18 years of age
Growth charts for Down's syndrome from birth to 18 years of age
复制标题
DOI：
10.1136/adc.87.2.97
复制
发表时间：
2002-08-01
影响因子：
5.2
通讯作者：
Annerén, G
中科院分区：
文献类型：
--
作者：
Myrelid, Å;Gustafsson, J;Annerén, G
背景：唐氏综合征（DS）儿童的生长发育与正常儿童明显不同。DS特异性生长图表的使用对于诊断相关疾病非常重要，如腹腔疾病和甲状腺功能减退症，这些疾病可能进一步损害生长。目的：介绍瑞典DS特异性生长图表。生长图表是基于354名DS患者的4832次检查的纵向和横截面数据的组合结果：男203例，女151例，平均身长48 cm。最终身高，男性161.5厘米，女性147.5厘米，达到相对年轻的年龄，分别为16和15岁。男孩的平均出生体重为3.0公斤，女孩为2.9公斤。在18岁时，31%的男性和36%的女性的体重指数（BMI）>25 kg/m2。头部生长受损，导致婴儿猝死综合征的头围-0.5（瑞典标准）在出生时减少到-2.0在4岁的age.Conclusion：尽管生长迟缓的性别之间的身高差异是相同的，发现在健康的个人。尽管青春期出现得有些早，但图表显示DS个体的青春期生长速度降低。我们的生长图表显示，患有DS的欧洲男孩比相应的美国男孩更高，而患有DS的欧洲女孩虽然更轻，但与相应的美国女孩身高相似。
Background: Growth in children with Down's syndrome (DS) differs markedly from that of normal children. The use of DS specific growth charts is important for diagnosis of associated diseases, such as coeliac disease and hypothyroidism, which may further impair growth.Aims: To present Swedish DS specific growth charts.Methods: The growth charts are based on a combination of longitudinal and cross sectional data from 4832 examinations of 354 individuals with DS (203 males, 15 1 females), born in 1970-97.Results: Mean birth length was 48 cm in both sexes. Final height, 161.5 cm for males and 147.5 cm for females, was reached at relatively young ages, 16 and 15 years, respectively. Mean birth weight was 3.0 kg for boys and 2.9 kg for girls. A body mass index (BMI) >25 kg/m(2) at 18 years of age was observed in 31% of the males and 36% of the females. Head growth was impaired, resulting in a SIDS for head circumference of -0.5 (Swedish standard) at birth decreasing to -2.0 at 4 years of age.Conclusion: Despite growth retardation the difference in height between the sexes is the same as that found in healthy individuals. Even though puberty appears somewhat early, the charts show that DS individuals have a decreased pubertal growth rate. Our growth charts show that European boys with DS are taller than corresponding American boys, whereas European girls with DS, although being lighter, have similar height to corresponding American girls.