Developmental Biology of Coxiella burnetii
Developmental Biology of Coxiella burnetii
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DOI：
10.1007/978-94-007-4315-1_12
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Raghavan, Rahul
中科院分区：
文献类型：
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作者：
Minnick, Michael F.;Raghavan, Rahul
伯纳氏杆菌的两期发育周期对病原体的自然史和生存至关重要。一种小的休眠细胞形态（小细胞变异或SCV）允许这种专性细胞内细菌在宿主细胞外存活较长时间，抵抗对大多数原核生物致命的环境条件，是真核生物宿主遇到的主要感染阶段。相比之下，一个大的、代谢活跃的形态（大细胞变异或LCV）提供了在宿主细胞酸化的寄生液泡（pv）内的药物复制。Coxiella从LCV到SCV再到LCV的形态发生过程中所涉及的显著生理变化、差异基因表达以及调控和结构成分是该病原体的迷人属性，本章将对其进行综述。
The biphasic developmental cycle of Coxiella burnetii is central to the pathogen's natural history and survival. A small, dormant cell morphotype (the small-cell variant or SCV) allows this obligate intracellular bacterium to persist for extended periods outside of host cells, resist environmental conditions that would be lethal to most prokaryotes, and is the major infectious stage encountered by eukaryotic hosts. In contrast, a large, metabolically-active morphotype (the large-cell variant or LCV) provides for replication of the agent within acidified parasitophorous vacuoles (PVs) of a host cell. The marked physiological changes, differential gene expression, and the regulatory and structural components involved in Coxiella's morphogenesis from LCV to SCV and back to the LCV are fascinating attributes of the pathogen and are reviewed in this chapter.