Disulfide bond formation in peptides.
Disulfide bond formation in peptides.
复制标题
DOI：
10.1002/0471140864.ps1806s23
复制
发表时间：
2001-05-01
影响因子：
--
通讯作者：
Barany, George
中科院分区：
文献类型：
--
作者：
Chen, Lin;Annis, Ioana;Barany, George
二硫键的形成通常是肽合成的关键最后阶段。有令人信服的证据表明，二硫键模式对于许多天然肽和蛋白质序列的折叠和结构稳定至关重要，而将二硫键人工引入天然或设计的肽中通常可以提高生物活性/特异性和稳定性。该装置提供了高度选择性且最先进的程序菜单，可用于在不同复杂性的目标中建立分子内或分子间二硫键。
The formation of disulfide bridges is often a crucial final stage in peptide synthesis. There is compelling evidence that the disulfide pattern can be critical in the folding and structural stabilization of many natural peptide and protein sequences, while the artificial introduction of disulfide bridges into natural or designed peptides may often improve biological activities/specificities and stabilities. This unit provides a highly selective, albeit state-of-the-art, menu of procedures that can be performed to establish intramolecular or intermolecular disulfide bridges in targets of varying complexities.