Function
Function
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DOI：
10.32388/xkp7qn
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发表时间：
2020-03
期刊：
影响因子：
--
通讯作者：
S. Bonser
中科院分区：
文献类型：
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作者：
S. Bonser
预测一个人何时死亡的能力对于衰老的许多研究问题都非常有用。已经提出了一种用于预测模式生物黑腹果蝇（Drosophila melanogaster）死亡的技术，该技术依赖于果蝇肠道系统的渗透性的增加，从而允许来自饮食的染料在死亡前不久渗透到果蝇的身体。在这项研究中，我们试图验证这一说法在一个大型队列研究中使用不同的人口D。黑腹菌和不同的染料我们发现，只有大约50%的个体在死亡前显示出可见的染料分布。这个数字并不随所使用的染料而显著变化。大多数苍蝇在死亡前会变成蓝色，并在死亡后24小时内变成蓝色。染料对果蝇的平均寿命也有可测量的影响。这些结果往往会限制该方法的实用性，这取决于该方法的应用。
The ability to predict when an individual will die can be extremely useful for many research problems in aging. A technique for predicting death in the model organism, Drosophila melanogaster , has been proposed which relies on an increase in the permeability of the fly intestinal system, allowing dyes from the diet to permeate the body of the fly shortly before death. In this study we sought to verify this claim in a large cohort study using different populations of D . melanogaster and different dyes. We found that only about 50% of the individuals showed a visible distribution of dye before death. This number did not vary substantially with the dye used. Most flies that did turn a blue color before death did so within 24 hours of death. There was also a measurable effect of the dye on the fly mean longevity. These results would tend to limit the utility of this method depending on the application the method was intended for.