Chromosome translocations in workers exposed to benzene.
Chromosome translocations in workers exposed to benzene.
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DOI：
10.1093/jncimonographs/lgn010
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发表时间：
2008-01-01
期刊：
影响因子：
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通讯作者：
Smith, Martyn T
中科院分区：
文献类型：
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作者：
McHale, Cliona M;Lan, Qing;Smith, Martyn T
由于苯与急性髓系白血病和淋巴瘤的风险升高有关，因此我们探讨了苯暴露对 t(8;21)、t(15;17) 和 t(14;18) 易位水平的影响。正常个体的循环淋巴细胞也常常含有t(14;18)。定量聚合酶链式反应分析显示，37 名接触苯的工人血液中 t(14;18) 水平下降，其中只有 16.2% 的工人有 10 个或更多拷贝的 t(14;18) BCL-2/IgH 融合基因/microg DNA，而 20 名对照工人的这一比例为 55%（根据 Fisher 精确检验，P = .0063）。这种下降可能与循环 B 淋巴细胞特定亚型的免疫毒性有关，但数据不支持使用 t(14;18) 作为苯暴露人群淋巴瘤风险增加的生物标志物。 88 名个体（31 名对照者和 57 名暴露者）均未表现出可检测到的 t(8;21) 转录物，虽然在两个个体中检测到 t(15;17) 转录物，但结果尚无定论，因为一个人暴露了，另一个人未暴露。
As benzene has been linked with elevated risk of both acute myeloid leukemia and lymphoma, we explored the effect of benzene exposure on levels of t(8;21), t(15;17), and t(14;18) translocations. Circulating lymphocytes of normal individuals also often contain t(14;18). Quantitative polymerase chain reaction analysis showed that 37 workers with benzene exposure had a decreased level of t(14;18) in their blood with only 16.2% having 10 or more copies of the t(14;18) BCL-2/IgH fusion gene/microg DNA, as opposed to 55% of 20 controls (P = .0063 by Fisher's exact test). This decline may be related to the immunotoxicity to specific subtypes of circulating B-lymphocytes, but the data do not support the use of t(14;18) as a biomarker of increased lymphoma risk in benzene-exposed populations. None of 88 individuals (31 controls and 57 exposed) exhibited detectable t(8;21) transcripts, and while t(15;17) transcripts were detected in two individuals, the result is inconclusive as one was exposed and the other was unexposed.