Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women:: Japanese population-based osteoporosis (JPOS) study
Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women:: Japanese population-based osteoporosis (JPOS) study
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DOI：
10.1093/jn/136.5.1323
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发表时间：
2006-05-01
影响因子：
4.2
通讯作者：
Yoneshima, H
中科院分区：
文献类型：
--
作者：
Ikeda, Y;Iki, M;Yoneshima, H
日本发酵大豆（日本的纳豆）含有大量的甲基萘醌-7，可能有助于预防骨质疏松症的发展。我们评估了习惯性纳豆摄入量与骨矿物质密度（BMD）和BMD随时间变化的关系的可能性，这些女性参加了一项大型代表性队列研究（日本人群骨质疏松症研究：JPOS研究）。测量944名女性（20-79岁）在基线和3年后进行的随访时脊柱、髋部和前臂的BMD。在这两种情况下，通过FFQ评估饮食纳豆摄入量。其他协变量包括年龄、身高、体重、生活方式因素、膳食钙摄入量和其他大豆制品的摄入量也进行了测量。在绝经后妇女中，随着习惯性纳豆摄入量的增加，基线时的髋部总BMD增加（趋势P = 0.0034），尽管其他骨骼部位的情况并非如此。纳豆摄入量与绝经后妇女股骨颈（P < 0.0001）和桡骨远端1/3（P = 0.0002）BMD变化率之间存在显著正相关。即使在调整协变量后，股骨颈的相关性仍然存在。在绝经后妇女中，豆腐或其他豆制品的摄入量与BMD变化率之间没有显著相关性。摄入纳豆可能有助于防止绝经后骨质流失，通过甲基萘醌7或生物可利用的维生素B1的作用，这是更丰富的纳豆比其他大豆产品。
Japanese fermented soybeans (natto in Japanese), which contain a large amount of menaquinone-7, may help prevent the development of osteoporosis. We assessed the possibility of an association between habitual natto intake and bone mineral density (BMD) and BMD change over time in healthy Japanese women who participated in a large representative cohort study (Japanese Population-based Osteoporosis Study: JPOS study). The BMD was measured at the spine, hip, and forearm in 944 women (20-79 y old) at baseline and at a follow-up conducted 3 y later. Dietary natto intake was assessed by a FFQ on both occasions. Additional covariates including age, height, weight, lifestyle factors, dietary calcium intake, and the intake of other soybean products, were also measured. The total hip BMD at baseline increased (P for trend = 0.0034) with increasing habitual natto intake in the postmenopausal women, although this was not the case at other skeletal sites. There were significant positive associations between natto intake and the rates of changes in BMD at the femoral neck (P < 0.0001) and at the distal third of the radius (P = 0.0002) in the postmenopausal women. The association in the femoral neck persisted even after adjusting for covariates. No significant association was observed between the intake of tofu or other soybean products and the rate of BMD change in the postmenopausal women. Natto intake may help prevent postmenopausal bone loss through the effects of menaquinone 7 or bioavailable isoflavones, which are more abundant in natto than in other soybean products.