Fibrinogen in relation to personal history of prevalent hypertension, diabetes, stroke, intermittent claudication, coronary heart disease, and family history: the Scottish Heart Health Study.
Fibrinogen in relation to personal history of prevalent hypertension, diabetes, stroke, intermittent claudication, coronary heart disease, and family history: the Scottish Heart Health Study.
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纤维蛋白原与流行高血压、糖尿病、中风、间歇性跛行、冠心病和家族史的个人史相关：苏格兰心脏健康研究。
DOI：
10.1136/hrt.69.4.338
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发表时间：
1993
影响因子：
--
通讯作者：
H. Tunstall
中科院分区：
文献类型：
--
作者：
Amanda J. Lee;G. Lowe;M. Woodward;H. Tunstall
目的：确定血浆纤维蛋白原与早发性心脏病家族史、高血压、糖尿病、中风、冠心病个人病史以及间歇性跛行存在的关系。设计：对苏格兰22个地方政府区进行随机人口调查。参与者：10359名年龄在40至59岁之间的男女。8824测定血浆纤维蛋白原。主要观察指标：血浆纤维蛋白原浓度。结果：有心脏病家族史或有高血压、糖尿病、中风或间歇性跛行病史的人血浆纤维蛋白原浓度均高于无病史的人。与无心血管或相关疾病的参与者相比(男性：2.27 (SE = 0.01) g/l, n = 3367；女性：2.34 (0.01)g/l, n = 3096)，预定义的心肌梗死病例(男性：2.51 (0.02)g/l, n = 248；女性：2.63 (0.04)g/l, n = 72)或心绞痛(男性：2.45 (0.02)g/l, n = 394；女性：2.50 (0.02)g/l, n = 398)血浆纤维蛋白原浓度显著升高（p < 0.001）。在对其他10个冠状动脉危险因素进行校正后，在两性血浆纤维蛋白原浓度的所有四分位数中，心肌梗死的优势比有明显的线性趋势。同样，心绞痛的风险随着纤维蛋白原浓度的增加而线性增加，尽管在女性中线性趋势的测试是NS。结论：这项大规模人群研究证实，血浆纤维蛋白原不仅是冠心病和中风的危险因素，而且还与早发心脏病家族史、高血压、糖尿病和间歇性跛行存在的个人病史有关。
OBJECTIVE--To determine the relations of plasma fibrinogen to family history of premature heart disease, personal history of hypertension, diabetes, stroke, coronary heart disease, and to presence of intermittent claudication. DESIGN--Random population survey across 22 local government districts in Scotland. PARTICIPANTS--10,359 men and women aged 40 to 59 years. Plasma fibrinogen was measured in 8824. MAIN OUTCOME MEASURE--Plasma fibrinogen concentration. RESULTS--Persons with a family history of heart disease or a personal history of high blood pressure, diabetes, stroke, or presence of intermittent claudication all had higher plasma fibrinogen concentrations than those without. When compared with participants without cardiovascular or related disease (men: 2.27 (SE = 0.01) g/l, n = 3367; women 2.34 (0.01) g/l, n = 3096), predefined cases of either myocardial infarction (men: 2.51 (0.02) g/l, n = 248; women: 2.63 (0.04) g/l, n = 72) or angina (men: 2.45 (0.02) g/l, n = 394; women: 2.50 (0.02) g/l, n = 398) had significantly higher plasma fibrinogen concentrations (p < 0.001). After adjustment for 10 other coronary risk factors, there was a noticeable linear trend in the odds ratios for myocardial infarction across all quartiles (quarters) of plasma fibrinogen concentrations in both sexes. Similarly, the risk of angina increased linearly with increasing fibrinogen concentrations, although the test for a linear trend was NS among women. CONCLUSIONS--This large population study confirms that plasma fibrinogen is not only a risk factor for coronary heart disease and stroke, but it is also raised with family history of premature heart disease and with personal history of hypertension, diabetes, and presence of intermittent claudication.
DOI：
10.1001/jama.1987.03400090067035
发表时间：
1987-09
期刊：
JAMA
影响因子：
--
作者：
W. Kannel;P. Wolf;W. Castelli;R. D'Agostino
通讯作者：
W. Kannel;P. Wolf;W. Castelli;R. D'Agostino
影响因子：
4.8
作者：
MYERS, RH;KIELY, DK;KANNEL, WB
通讯作者：
KANNEL, WB