Neighbourhood-level social deprivation and the risk of recurrent heart failure hospitalizations in type 2 diabetes.

Neighbourhood-level social deprivation and the risk of recurrent heart failure hospitalizations in type 2 diabetes.
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DOI:
10.1111/dom.15174
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发表时间:
2023-10
影响因子:
5.8
通讯作者:
Sattar, Naveed
Sattar, Naveed
中科院分区:
医学2区
文献类型:
--
作者:
Deo, Salil V. V.;Al-Kindi, Sadeer;Motairek, Issam;Elgudin, Yakov E. E.;Gorodeski, Eiran;Nasir, Khurram;Rajagopalan, Sanjay;Petrie, Mark C. C.;Sattar, Naveed

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The importance of type 2 diabetes mellitus (T2D) in heart failure hospitalizations (HFH) is acknowledged. As information on the prevalence and influence of social deprivation on HFH is limited, we studied this issue in a racially diverse cohort. Linking data from US Veterans with stable T2D (without prevalent HF) with a zip-code derived population-level social deprivation index (SDI), we grouped them according to increasing SDI as follows: SDI: group I: ≤20; II: 21–40; III: 41–60; IV: 61–80; and V (most deprived) 81–100. Over a 10-year follow-up period, we identified the total (first and recurrent) number of HFH episodes for each patient and calculated the age-adjusted HFH rate [per 1000 patient-years (PY)]. We analysed the incident rate ratio between SDI groups and HFH using adjusted analyses. In 1 012 351 patients with T2D (mean age 67.5 years, 75.7% White), the cumulative incidence of first HFH was 9.4% and 14.2% in SDI groups I and V respectively. The 10-year total HFH rate was 54.8 (95% CI: 54.5, 55.2)/1000 PY. Total HFH increased incrementally from SDI group I [43.3 (95% CI: 42.4, 44.2)/1000 PY] to group V [68.6 (95% CI: 67.8, 69.9)/1000 PY]. Compared with group I, group V patients had a 53% higher relative risk of HFH. The negative association between SDI and HFH was stronger in Black patients (SDI × Race pinteraction < .001). Social deprivation is associated with increased HFH in T2D with a disproportionate influence in Black patients. Strategies to reduce social disparity and equalize racial differences may help to bridge this gap.
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