Improved mapping of (pharmacologically induced neuronal activation using the IRON technique with superparamagnetic blood pool agents
Improved mapping of (pharmacologically induced neuronal activation using the IRON technique with superparamagnetic blood pool agents
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DOI：
10.1002/jmri.1215
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发表时间：
2001-11-01
影响因子：
4.4
通讯作者：
Jenkins, BG
中科院分区：
文献类型：
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作者：
Chen, YCI;Mandeville, JB;Jenkins, BG
使用功能磁共振成像（fMRI）技术评估药理刺激对于了解许多脑部疾病（例如药物滥用、精神分裂症、癫痫或神经退行性疾病）的神经递质动力学具有巨大的潜力。遗憾的是，常见场强（例如 1.5 或 3 T）下的血氧水平依赖性 (BOLD) 成像的灵敏度和对比度噪声比 (CNR) 非常低。我们在这里展示了使用具有长血浆半衰期的血管内超顺磁性氧化铁造影剂来评估与使用安非他明或可卡因类似物 2β-甲甲氧基-3β-(4-氟苯基)托烷 (CFT) 的多巴胺能刺激相关的血流动力学变化的效用。我们将此技术称为氧化铁纳米颗粒 (IRON) 增加松弛。这里获得的结果表明，即使场强高达 4.7 T，与 BOLD 成像相比，CNR 也能增加 2-3 倍，从而导致统计功效增加一个数量级以上，并且对使用 BOLD 成像难以观察到的大脑区域的血流动力学变化的敏感性大大提高。此外，与传统的 BOLD 成像相比，使用血管内造影剂可以测量有意义的生理参数（相对脑血容量 (rCBV)）。 (C) 2001 Wiley-Liss, Inc.
The use of functional magnetic resonance imaging (fMRI) techniques for evaluation of pharmacologic stimuli has great potential for understanding neurotransmitter dynamics for a number of brain disorders, such as drug abuse, schizophrenia, epilepsy, or neurodegeneration. Unfortunately, blood oxygenation level-dependent (BOLD) imaging at common fields strengths, such as 1.5 or 3 T, has very low sensitivity and contrast-to-noise ratios (CNRs). We demonstrate here the utility of using an intravascular superparamagnetic iron oxide contrast agent with a long plasma half-life for evaluation of hemodynamic changes related to dopaminergic stimuli using amphetamine or the cocaine analog 2beta-carbomethoxy-3beta-(4-fluorophenyl)tropane (CFT). We refer to this technique as increased relaxation with iron oxide nanoparticles (IRON). Results obtained here show that even at field strengths as high as 4.7 T, one can obtain increases in CNR by factors of 2-3 over BOLD imaging that lead to greater than an order of magnitude increase in statistical power with greatly increased sensitivity to hemodynamic changes in brain regions difficult to observe using BOLD imaging. Furthermore, use of the intravascular contrast agent allows for a meaningful physiologic parameter to be measured (relative cerebral blood volume (rCBV)), compared to conventional BOLD imaging. (C) 2001 Wiley-Liss, Inc.