International patterns of tuberculosis and the prevalence of symptoms of asthma, rhinitis, and eczema
International patterns of tuberculosis and the prevalence of symptoms of asthma, rhinitis, and eczema
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DOI：
10.1136/thorax.55.6.449
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发表时间：
2000-06-01
期刊：
影响因子：
10
通讯作者：
Weiland, S
中科院分区：
文献类型：
--
作者：
von Mutius, E;Pearce, N;Weiland, S
背景--在来自23个国家的85个中心进行了结核病报告率与哮喘、过敏性鼻结膜炎和特应性湿疹症状患病率之间关系的生态学分析，这些中心有标准化数据。这些国家主要包括欧洲国家以及美国、加拿大、澳大利亚和新西兰。方法-结核病报告率来自世界卫生组织。235477名13-14岁儿童哮喘、鼻炎和湿疹症状的患病率数据基于对儿童哮喘和过敏国际研究（ISAAC）书面和视频问卷的回答。分析调整为国民生产总值（GNP）作为估计的水平的affluency. Results-TB的通知率显着负相关的喘息和哮喘的终生患病率和12个月期间喘息在休息时的患病率评估的视频问卷。结核病报告率每10万人增加25例，喘息患病率绝对下降4.7%。过敏性鼻结膜炎的症状，在过去的12个月内呈负相关的结核病的通知率，但有没有其他显着的关联与其他ISAAC的问题过敏性鼻结膜炎或过敏性eczymes. Conclusions，这些研究结果是一致的，最近的实验证据表明，暴露于结核分枝杆菌可能会降低患哮喘的风险。
Background-An ecological analysis was conducted of the relationship between tuberculosis notification rates and the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema in 85 centres from 23 countries in which standardised data are available. These essentially comprised countries in Europe as well as the USA, Canada, Australia, and New Zealand.Methods-Tuberculosis notification rates were obtained from the World Health Organization. Data on the prevalence of symptoms of asthma, rhinitis, and eczema in 235 477 children aged 13-14 years were based on the responses to the written and video questionnaires from the International Study of Asthma and Allergies in Childhood (ISAAC). The analysis was adjusted for gross national product (GNP) as an estimate of the level of affluence.Results-Tuberculosis notification rates were significantly inversely associated with the lifetime prevalence of wheeze and asthma and the 12 month period prevalence of wheeze at rest as assessed by the video questionnaire. An increase in the tuberculosis notification rates of 25 per 100 000 was associated with an absolute decrease in the prevalence of wheeze ever of 4.7%. Symptoms of allergic rhinoconjunctivitis in the past 12 months were inversely associated with tuberculosis notification rates, but there were no other significant associations with other ISAAC questions on allergic rhinoconjunctivitis or atopic eczema.Conclusions-These findings are consistent with recent experimental evidence which suggests that exposure to Mycobacterium tuberculosis may reduce the risk of developing asthma.