Quetiapine and repetitive transcranial magnetic stimulation ameliorate depression-like behaviors and up-regulate the proliferation of hippocampal-derived neural stem cells in a rat model of depression: The involvement of the BDNF/ERK signal pathway
Quetiapine and repetitive transcranial magnetic stimulation ameliorate depression-like behaviors and up-regulate the proliferation of hippocampal-derived neural stem cells in a rat model of depression: The involvement of the BDNF/ERK signal pathway
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喹硫平和重复经颅磁刺激可改善抑郁症大鼠模型中的抑郁样行为并上调海马源性神经干细胞的增殖：BDNF/ERK 信号的参与
DOI：
10.1016/j.pbb.2015.07.005
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发表时间：
2015-09-01
影响因子：
3.6
通讯作者：
Tan, Qing-rong
中科院分区：
文献类型：
--
作者：
Chen, Yi-huan;Zhang, Rui-guo;Tan, Qing-rong
奎硫平(QUE)和重复经颅磁刺激(RTMS)被认为是治疗抑郁症的单一疗法或治疗难治性抑郁症的辅助疗法，但其潜在机制尚不清楚。本研究旨在观察Que和rTMS联合治疗对雄性SD大鼠抑郁样行为、海马神经元增殖以及体内和体外磷酸化细胞外信号调节蛋白激酶(pERK1/2)和脑源性神经营养因子(BDNF)表达的影响。给予Que和rTMS不仅可以逆转慢性不可预知应激(CUS)大鼠的抑郁样行为，而且可以恢复PERK1/2和BDNF的蛋白表达和海马神经元的增殖。此外，Que和rTMS可促进海马源性神经干细胞(NSCs)的增殖，增加pERK1/2和BDNF的表达，这些作用可被U0126阻断。综上所述，上述结果提示Que和rTMS的抗抑郁作用可能与激活BDNF/ERK信号通路和上调海马区细胞增殖有关。(C)2015 Elsevier Inc.保留所有权利。
Quetiapine (QUE) and repetitive transcranial magnetic stimulation (rTMS) have been considered to be possible monotherapies for depression or adjunctive therapies for the treatment of the resistant depression, but the underlying mechanisms remain unclear. The present study aimed to assess the effects of combined QUE and rTMS treatment on depressive-like behaviors, hippocampal proliferation, and the in vivo and in vitro expressions of phosphorylated extracellular signal-regulated protein kinase (pERK1/2) and brain-derived neurotrophic factor (BDNF) in male Sprague-Dawley rats. The administration of QUE and rTMS was determined not only to reverse the depressive-like behaviors of rats exposed to chronic unpredictable stress (CUS) but also to restore the protein expressions of pERK1/2 and BDNF and cell proliferation in the hippocampus. Additionally, QUE and rTMS promoted the proliferation and increased the expression of pERK1/2 and BDNF in hippocampal-derived neural stem cells (NSCs), and these effects were abolished by U0126. Taken together, these results suggest that the antidepressive-like effects of QUE and rTMS might be related to the activation of the BDNF/ERK signaling pathway and the up-regulation of cell proliferation in the hippocampus. (C) 2015 Elsevier Inc. All rights reserved.