Potential roles of BMP9 in liver fibrosis.
Potential roles of BMP9 in liver fibrosis.
复制标题
BMP9 在肝纤维化中的潜在作用。
DOI：
10.3390/ijms151120656
复制
发表时间：
2014-11-11
影响因子：
5.6
通讯作者：
Ge S
中科院分区：
文献类型：
--
作者：
Bi J;Ge S
肝纤维化是一种常见现象，与多种病理相关，其特征是细胞外基质过度沉积，导致进行性肝功能障碍。骨形态发生蛋白 9 (BMP9) 是 BMP 家族中最新发现的成员。 BMP9 以高亲和力与非实质肝细胞中的激活素受体样激酶 1 (ALK1) 和内皮糖蛋白结合。此外，BMP9激活Smad1/Smad5/Smad8并诱导肝细胞中靶基因分化抑制剂1（Id1）、hepcidin、Snail和共受体内皮糖蛋白的表达。尽管目前对 BMP9 在肝纤维化中的作用知之甚少，但据报道 BMP9 激活蛋白及其靶基因的存在与肝纤维化的发展有关。本文综述了BMP9与肝纤维化之间的间接联系，重点介绍了BMP9信号通路成员ALK1、内皮糖蛋白、Id1、hepcidin和Snail。对BMP9调节肝纤维化作用的观察可能有助于了解肝病的病理机制。此外，BMP9可以作为有效的生物标志物和治疗肝细胞纤维化的潜在治疗药物的靶点。
Liver fibrosis is a common phenomenon that is associated with several pathologies and is characterized by excessive extracellular matrix deposition that leads to progressive liver dysfunction. Bone morphogenetic protein 9 (BMP9) is the most recently discovered member of the BMP family. BMP9 bound with high affinity to activin receptor-like kinase 1 (ALK1) and endoglin in non-parenchymal liver cells. In addition, BMP9 activated Smad1/Smad5/Smad8 and induced the expression of the target genes inhibitor of differentiation 1 (Id1), hepcidin, Snail and the co-receptor endoglin in liver cells. Although the role of BMP9 in liver fibrosis is currently poorly understood, the presence of BMP9-activated proteins and its target genes have been reported to be associated with liver fibrosis development. This review summarizes the indirect connection between BMP9 and liver fibrosis, with a focus on the BMP9 signaling pathway members ALK1, endoglin, Id1, hepcidin and Snail. The observations on the role of BMP9 in regulating liver fibrosis may help in understanding the pathology mechanisms of liver disease. Furthermore, BMP9 could be served as a potent biomarker and the target of potential therapeutic drugs to treat hepatocytes fibrosis.
登录
查看更多内容
影响因子：
4.8
作者：
Brown, MA;Zhao, QH;Choe, S
通讯作者：
Choe, S
影响因子：
7
作者：
Finnson, K. W.;Parker, W. L.;Philip, A.
通讯作者：
Philip, A.
影响因子：
4.8
作者：
Kaimori, Aki;Potter, James;Koteish, Ayman
通讯作者：
Koteish, Ayman
影响因子：
46.9
作者：
Chen, C;Grzegorzewski, KJ;Birse, CE
通讯作者：
Birse, CE
影响因子：
5.1
作者：
Kang, Q;Sun, MH;He, TC
通讯作者：
He, TC