Pd-catalyzed stereospecific azide substitution of α,β-unsaturated γ,δ-epoxy esters with double inversion of configuration
Pd-catalyzed stereospecific azide substitution of α,β-unsaturated γ,δ-epoxy esters with double inversion of configuration
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DOI：
10.1002/anie.200500838
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发表时间：
2005-01-01
影响因子：
16.6
通讯作者：
Tanino, K
中科院分区：
文献类型：
--
作者：
Miyashita, M;Mizutani, T;Tanino, K
无环、环和光学活性的不饱和γ、δ-环氧酯被用于高立体选择性合成功能化氨基醇、氨基酸和α、α-二取代氨基酸。反应序列的关键步骤是构型的双重反转（见方案）。
(Chemical Equation Presented) Acyclic, cyclic, and optically active unsaturated γ, δ-epoxy esters are employed in a highly stereoselective synthesis of functionalized amino alcohols, amino acids, and α, α-disubstituted amino acids. The key step of the reaction sequence is a double inversion of configuration (see scheme).