The many shades of prion strain adaptation
The many shades of prion strain adaptation
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DOI：
10.4161/pri.27836
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发表时间：
2014-03-01
期刊：
影响因子：
2.3
通讯作者：
Baskakov, Ilia V.
中科院分区：
文献类型：
--
作者：
Baskakov, Ilia V.
在最近的几项研究中，通过接种体外产生的重组朊蛋白淀粉样纤维在动物中诱导传染性朊病毒病。淀粉样纤维的连续传播产生了一类新的合成来源的朊病毒株。在合成朊病毒的连续传播过程中观察到疾病表型和PrPSc特性的逐渐转化，这一过程类似于朊病毒株适应的现象。目前的文章讨论了朊病毒菌株适应现象，伴随着跨物种传播和同一宿主内发生的合成朊病毒的进化之间的显着相似之处。朊病毒菌株适应和合成株进化的两种替代机制进行了讨论。目前的文章强调了朊病毒传播障碍和应变适应的复杂性，并提出朊病毒适应的现象比以前认为的更常见。
In several recent studies transmissible prion disease was induced in animals by inoculation with recombinant prion protein amyloid fibrils produced in vitro. Serial transmission of amyloid fibrils gave rise to a new class of prion strains of synthetic origin. Gradual transformation of disease phenotypes and PrPSc properties was observed during serial transmission of synthetic prions, a process that resembled the phenomenon of prion strain adaptation. The current article discusses the remarkable parallels between phenomena of prion strain adaptation that accompanies cross-species transmission and the evolution of synthetic prions occurring within the same host. Two alternative mechanisms underlying prion strain adaptation and synthetic strain evolution are discussed. The current article highlights the complexity of the prion transmission barrier and strain adaptation and proposes that the phenomenon of prion adaptation is more common than previously thought.