The role of ATP in sleep regulation.
The role of ATP in sleep regulation.
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DOI：
10.3389/fneur.2011.00087
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发表时间：
2011
影响因子：
3.4
通讯作者：
Séi H
中科院分区：
文献类型：
--
作者：
Chikahisa S;Séi H
睡眠的功能之一是维持大脑的能量平衡。关于代谢途径如何与睡眠/觉醒调节相互作用有多种假设。证明睡眠与代谢稳态之间存在相互作用的一项重大发现是腺苷参与睡眠稳态。腺苷的积累由 ATP 提供，ATP 可以充当细胞中的能量货币。在细胞外，ATP 可以充当活性依赖性信号分子，特别是在神经元和神经胶质细胞（包括星形胶质细胞）之间的通讯方面。此外，细胞内 AMP/ATP 比率控制 AMP 激活蛋白激酶的活性，这是一种有效的能量调节剂，最近有报道称其在调节睡眠稳态中发挥作用。脑 ATP 可能支持调节睡眠/觉醒周期和睡眠稳态的多种功能。
One of the functions of sleep is to maintain energy balance in the brain. There are a variety of hypotheses related to how metabolic pathways interact with sleep/wake regulation. A major finding that demonstrates an interaction between sleep and metabolic homeostasis is the involvement of adenosine in sleep homeostasis. An accumulation of adenosine is supplied from ATP, which can act as an energy currency in the cell. Extracellularly, ATP can act as an activity-dependent signaling molecule, especially in regard to communication between neurons and glia, including astrocytes. Furthermore, the intracellular AMP/ATP ratio controls the activity of AMP-activated protein kinase, which is a potent energy regulator and is recently reported to play a role in the regulation of sleep homeostasis. Brain ATP may support multiple functions in the regulation of the sleep/wake cycle and sleep homeostasis.