Synthesis of diaryl ethers through the copper-promoted arylation of phenols with arylboronic acids. An expedient synthesis of thyroxine
Synthesis of diaryl ethers through the copper-promoted arylation of phenols with arylboronic acids. An expedient synthesis of thyroxine
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DOI：
10.1016/s0040-4039(98)00502-4
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发表时间：
1998-05-07
影响因子：
1.8
通讯作者：
West, TR
中科院分区：
文献类型：
--
作者：
Evans, DA;Katz, JL;West, TR
通过铜(II)促进的芳基硼酸和酚的偶联，在室温下很容易以高产率合成二芳基醚。该反应可以耐受两个偶联配对物上的各种取代基。这些反应条件允许酚类氨基酸进行无外消旋的芳基化，该方法已应用于甲状腺素的有效合成。 (C) 1998 Elsevier Science Ltd. 保留所有权利。
Diaryl ethers are readily synthesized in high yield at room temperature through the copper(II)-promoted coupling of arylboronic acids and phenols. The reaction is tolerant of a wide range of substituents on both coupling partners. These reaction conditions permit the racemization-free arylation of phenolic amino acids, methodology that has been applied to an efficient synthesis of thyroxine. (C) 1998 Elsevier Science Ltd. All rights reserved.