Charting the travels of copper in eukaryotes from yeast to mammals.
Charting the travels of copper in eukaryotes from yeast to mammals.
复制标题
DOI：
10.1016/j.bbamcr.2012.02.011
复制
发表时间：
2012-09
影响因子：
5.1
通讯作者：
Thiele, Dennis J.
中科院分区：
文献类型：
--
作者：
Nevitt, Tracy;Oehrvik, Helena;Thiele, Dennis J.
在整个进化过程中，所有生物体都利用铜 (Cu) 和铁 (Fe) 的氧化还原特性作为在生物学中发挥关键功能的蛋白质的辅助因子或结构决定因素。对于地球生物群落来说，铜生物化学使光合生物能够利用太阳能并将其转化为维持所有非光合生命形式存在的有机能。有机能以碳水化合物、氨基酸和脂肪酸等营养物质的形式转化，随后在细胞呼吸过程中释放，细胞呼吸本身是一个依赖铜的过程，并以 ATP 形式储存，用于驱动无数关键的生物过程，如酶催化的生物合成过程、细胞周围和跨膜的货物运输以及蛋白质降解。铜的生命支持特性对细胞提出了重大挑战，细胞不仅必须精确地平衡细胞内铜浓度，而且还必须陪伴这种氧化还原活性金属从细胞进入点到最终目的地，以避免不适当的生化相互作用或产生破坏性活性氧化物质（ROS）的可能性。在这篇综述中，我们绘制了铜从真菌和哺乳动物细胞的细胞外环境中的旅行，它在细胞质中的路径（由护送铜并将其输送到细胞内细胞器和蛋白质靶点的蛋白质和配体推断），以及它在哺乳动物体内的旅程。
Throughout evolution, all organisms have harnessed the redox properties of copper (Cu) and iron (Fe) as a cofactor or structural determinant of proteins that perform critical functions in biology. At its most sobering stance to Earth’s biome, Cu biochemistry allows photosynthetic organisms to harness solar energy and convert it into the organic energy that sustains the existence of all nonphotosynthetic life forms. The conversion of organic energy, in the form of nutrients that include carbohydrates, amino acids and fatty acids, is subsequently released during cellular respiration, itself a Cu-dependent process, and stored as ATP that is used to drive a myriad of critical biological processes such as enzyme-catalyzed biosynthetic processes, transport of cargo around cells and across membranes, and protein degradation. The life-supporting properties of Cu incur a significant challenge to cells that must not only exquisitely balance intracellular Cu concentrations, but also chaperone this redox-active metal from its point of cellular entry to its ultimate destination so as to avert the potential for inappropriate biochemical interactions or generation of damaging reactive oxidative species (ROS). In this review we chart the travels of Cu from the extracellular milieu of fungal and mammalian cells, its path within the cytosol as inferred by the proteins and ligands that escort and deliver Cu to intracellular organelles and protein targets, and its journey throughout the body of mammals.
登录
查看更多内容
影响因子：
5.5
作者：
Arredondo, M;Muñoz, P;Núñez, MT
通讯作者：
Núñez, MT
影响因子：
5.6
作者：
Bertinato, Jesse;Duval, Sebastien;L'Abbe, Mary R.
通讯作者：
L'Abbe, Mary R.
影响因子：
3.6
作者：
Ding C;Yin J;Tovar EM;Fitzpatrick DA;Higgins DG;Thiele DJ
通讯作者：
Thiele DJ
影响因子：
2.8
作者：
Beaudoin, Jude;Thiele, Dennis J.;Puig, Sergi
通讯作者：
Puig, Sergi
影响因子：
4.8
作者：
Bertinato, J;L'Abbé, MR
通讯作者：
L'Abbé, MR