A comparison of methods for correlated ordinal measures with ophthalmic applications.
A comparison of methods for correlated ordinal measures with ophthalmic applications.
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相关顺序测量方法与眼科应用的比较。
DOI：
10.1002/sim.4780141803
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发表时间：
1995
影响因子：
2
通讯作者：
Klein,R
中科院分区：
文献类型：
--
作者：
Gange,SJ;Linton,KL;Scott,AJ;DeMets,DL;Klein,R
在眼科领域的许多临床试验和流行病学调查中，配对有序数据通常通过视网膜照片的详细分级来收集。分析这些数据的一种方法是将广义估计方程（GEE）方法扩展到具有累积链接函数的多项式数据。然而，在开发这种先进技术之前，眼科医生开发了一种方法，将患者双眼的顺序反应结合为新顺序量表上的单个人水平反应。这两种方法的回归系数之间的关系是作为眼睛之间的相关性的函数导出的。我们调查的适用性，这一结果和标准误差的关系，在模拟实验中，并在一个例子，从威斯康星州糖尿病视网膜病变的流行病学研究。
For many clinical trials and epidemiologic investigations in the field of ophthalmology, paired ordinal data are often collected through the detailed grading of retinal photographs. One method for analysis of these data is the extension of the generalized estimating equation (GEE) methodology to multinomial data with cumulative link functions. Prior to the development of this advanced technique, however, ophthalmologists developed a method of combining the ordinal responses of both eyes of a patient into a single person‐level response on a new ordinal scale. A relationship between the regression coefficients of these two methods is derived as a function of the correlation between eyes. We investigate the applicability of this result and the relationship of the standard errors in simulation experiments and in an example from the Wisconsin Epidemiologic Study of Diabetic Retinopathy.