Event related potential (ERP) evidence for selective impairment of verbal recollection in abstinent recreational methylenedioxymethamphetamine ("Ecstasy")/polydrug users
Event related potential (ERP) evidence for selective impairment of verbal recollection in abstinent recreational methylenedioxymethamphetamine ("Ecstasy")/polydrug users
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DOI：
10.1007/s00213-011-2249-9
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发表时间：
2011-08-01
影响因子：
3.4
通讯作者：
Parrott, Andrew C.
中科院分区：
文献类型：
--
作者：
Burgess, Adrian P.;Venables, Louise;Parrott, Andrew C.
摇头丸是一种娱乐性药物，其活性成分3，4-亚甲二氧基甲基苯丙胺（MDMA）主要作用于多巴胺能系统。虽然已知MDMA对动物具有神经毒性，但娱乐性使用摇头丸对人类的长期影响仍存在争议，但一种常见的报告后果是轻度认知障碍，特别是影响言语情景记忆。虽然事件相关电位（ERP）对我们理解人类记忆过程做出了重大贡献，但直到现在，它们还没有被应用于研究Eccentricular的长期影响。本研究的目的是用事件相关电位（ERPs）研究过去使用摇头丸对言语和非言语刺激的再认记忆的影响。我们比较了15名摇头丸/多种药物使用者与14名大麻使用者和13名非非法药物使用者的ERPs。尽管记忆表现相当，但摇头丸/多种药物使用者在左顶叶头皮部位表现出减弱的晚期阳性，这种效应仅在单词识别任务中发现，这与左半球认知功能不成比例地受到Eckonergic影响的证据一致，可能是因为Eckonergic系统横向不对称。在实验中，通过急性色氨酸耗竭降低中枢多巴胺能活动也会选择性地损害回忆，这也表明多巴胺能系统的重要性。总的来说，我们的研究结果表明，服用迷幻药的人，也服用各种其他药物，在一个被认为与回忆有关的特定ERP成分中表现出持久的异常。
Ecstasy is a recreational drug whose active ingredient, 3,4-methylenedioxymethamphetamine (MDMA), acts predominantly on the serotonergic system. Although MDMA is known to be neurotoxic in animals, the long-term effects of recreational Ecstasy use in humans remain controversial but one commonly reported consequence is mild cognitive impairment particularly affecting verbal episodic memory. Although event-related potentials (ERPs) have made significant contributions to our understanding of human memory processes, until now they have not been applied to study the long-term effects of Ecstasy. The aim of this study was to examine the effects of past Ecstasy use on recognition memory for both verbal and non-verbal stimuli using ERPs.We compared the ERPs of 15 Ecstasy/polydrug users with those of 14 cannabis users and 13 non-illicit drug users as controls.Despite equivalent memory performance, Ecstasy/polydrug users showed an attenuated late positivity over left parietal scalp sites, a component associated with the specific memory process of recollection.This effect was only found in the word recognition task which is consistent with evidence that left hemisphere cognitive functions are disproportionately affected by Ecstasy, probably because the serotonergic system is laterally asymmetrical. Experimentally, decreasing central serotonergic activity through acute tryptophan depletion also selectively impairs recollection, and this too suggests the importance of the serotonergic system. Overall, our results suggest that Ecstasy users, who also use a wide range of other drugs, show a durable abnormality in a specific ERP component thought to be associated with recollection.