Polymorphisms in biotransformation enzymes and the risk for recurrent early pregnancy loss.
Polymorphisms in biotransformation enzymes and the risk for recurrent early pregnancy loss.
复制标题
生物转化酶的多态性和复发性早期妊娠流产的风险。
DOI：
10.1093/molehr/6.5.474
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发表时间：
2000
影响因子：
4
通讯作者：
E. Steegers
中科院分区：
文献类型：
--
作者：
P. Zusterzeel;W.L.D.M. Nelen;H. Roelofs;W.H.M. Peters;Henk J. Blom;E. Steegers
I相药物代谢酶和II相解毒酶之间的不平衡可能有助于先兆子痫的发展。I相酶细胞色素P450基因的多态性变体可能导致解毒作用增加，而II相酶谷胱甘肽S-转移酶基因的多态性可能导致解毒作用受损。胎盘和蜕膜中含量最多的是谷胱甘肽S-转移酶P1-1，因此它在生殖中可能特别重要。我们研究了187例复发性早孕流产妇女和109例无复杂产科史妇女中这些酶的多态性变异频率。提取DNA，随后使用基于聚合酶链反应的基因分型测定。χ（2）分析和Fisher精确检验用于统计学评价。谷胱甘肽S-转移酶P1 b-1b基因型在复发性早孕流产妇女中的频率显著高于对照组（12%对5%，P = 0.03），特别是在喝咖啡（P = 0.02）或吸烟（P = 0.04）的妇女中。其他谷胱甘肽S-转移酶和细胞色素P450基因的多态性发生同样频繁的情况下和对照。总之，谷胱甘肽S-转移酶P1 b-1b基因型的发生，导致谷胱甘肽S-转移酶Pi酶活性降低，因此胎盘解毒功能受损，可能是反复早孕丢失的危险因素。
An imbalance between phase I drug metabolizing enzymes and phase II detoxification enzymes may contribute to the development of pre-eclampsia. Polymorphic variants in the phase I enzyme, cytochrome P450 genes may lead to increased toxification, whereas polymorphisms in the phase II enzyme, glutathione S-transferase genes may result in impaired detoxification. Most abundant in placenta and decidua is glutathione S-transferase P1-1, which may therefore be of particular importance in reproduction. We studied the frequencies of polymorphic variants in those enzymes in 187 women with recurrent early pregnancy loss and in 109 women with an uncomplicated obstetric history. DNA was extracted and subsequently polymerase chain reaction based genotyping assays were used. chi(2)-Analysis and Fisher's exact test were used for statistical evaluation. The glutathione S-transferase P1b-1b genotype was found significantly more often in women with recurrent early pregnancy loss than in controls (12% versus 5%, P = 0.03), in particular in those who consumed coffee (P = 0.02) or smoked cigarettes (P = 0.04). Polymorphisms in other glutathione S-transferase and cytochrome P450 genes occurred equally frequently in cases and controls. In conclusion, the occurrence of the glutathione S-transferase P1b-1b genotype, leading to lower glutathione S-transferase Pi enzyme activity and consequently to impaired placental detoxification, may represent a risk factor for recurrent early pregnancy loss.
复发性自然流产、吸烟以及 NAT2 和 GSTM1 基因多态性的风险。
DOI：
--
发表时间：
1998
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Mendola,P;Moysich,KB;Freudenheim,JL;Shields,PG;Schisterman,EF;Graham,S;Vena,JE;Marshall,JR;Ambrosone,CB
通讯作者：
Ambrosone,CB
影响因子：
11.4
作者：
Kim, Min Hwan;Kim, Jongshin;Kim, Joon
通讯作者：
Kim, Joon
影响因子：
158.5
作者：
Ness, RB;Grisso, JA;Kline, J
通讯作者：
Kline, J