Associations between symptom severity and treatment burden in people living with HIV.
Associations between symptom severity and treatment burden in people living with HIV.
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DOI：
10.1111/jan.14461
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发表时间：
2020-09
影响因子：
3.8
通讯作者：
Webel A
中科院分区：
文献类型：
--
作者：
Schreiner N;Perazzo J;Digennaro S;Burant C;Daly B;Webel A
研究艾滋病毒感染者症状严重程度与治疗负担之间的关系。相关性，二次分析的数据，从参与者诊断为艾滋病毒登记在一个描述性的，横断面研究检查身体活动模式。我们使用2016年3月至2017年2月收集的自我报告数据分析了103名男性和女性的数据。我们的主要统计分析包括解释性多变量建模，其中个体PROMIS-29评分代表使用治疗负担问卷-13测量的症状严重程度和治疗负担。更严重的症状与更高水平的累积治疗负担以及更高水平的特定任务药物和体力活动负担相关。多元回归分析显示，疲劳是累积治疗负担以及特定任务药物和体力活动治疗负担的危险因素。多变量模型的效应量范围从小（0.11）到中等（0.16）。此外，事后分析显示疲劳和其他测量症状之间存在很强的相关性。研究结果支持现有的治疗负担文献，包括在临床环境中结合治疗负担筛查解决症状严重程度的重要性。结果还表明，侧重于减少疲劳的临床干预措施可以减轻艾滋病毒感染者的治疗负担。疲劳和其他症状之间的强相关性表明，通过解决其他高度聚集的症状（如抑郁症）来减轻疲劳的潜力。表现出较高疲劳程度的艾滋病毒感染者面临治疗负担和自我管理依从性较差的高风险。临床医生在制定、调整和修改干预措施时，应考虑纳入症状和治疗负担评估，以改善艾滋病毒和其他共病状况的自我管理。
To examine the association between symptoms severity and treatment burden in people living with HIV. Correlational, secondary analysis of data from participants diagnosed with HIV enrolled in a descriptive, cross-sectional study examining physical activity patterns. We analysed data from 103 men and women using self-report data collected between March 2016 - February 2017. Our primary statistical analyses consisted of explanatory multivariate modelling with individual PROMIS-29 scores representing symptom severity and treatment burden measured using the Treatment Burden Questionnaire-13. Greater symptom severity was associated with higher levels of cumulative treatment burden as well as higher levels of task-specific medication and physical activity burden. Multivariate regression analyses revealed that fatigue was a risk factor of cumulative treatment burden as well as task-specific medication and physical activity treatment burden. Effect sizes of multivariate models ranged from small (0.11) to medium (0.16). Additionally, post hoc analyses showed strong correlations between fatigue and other measured symptoms. sFindings support extant treatment burden literature, including the importance of addressing symptom severity in conjunction with treatment burden screening in the clinical setting. Results also suggest clinical interventions focused on the reduction of fatigue could reduce treatment burden in people living with HIV. Strong correlations between fatigue and other symptoms indicate the potential for reducing fatigue by addressing other highly clustered symptoms, such as depression. People living with HIV exhibiting higher levels of fatigue are at high risk for treatment burden and poorer self-management adherence. Clinicians should consider incorporating symptom and treatment burden assessments when developing, tailoring and modifying interventions to improve self-management of HIV and other co-morbid conditions.
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影响因子：
120.7
作者：
Gunthard, Huldrych F.;Saag, Michael S.;Benson, Constance A.;del Rio, Carlos;Eron, Joseph J.;Gallant, Joel E.;Hoy, Jennifer F.;Mugavero, Michael J.;Sax, Paul E.;Thompson, Melanie A.;Gandhi, Rajesh T.;Landovitz, Raphael J.;Smith, Davey M.;Jacobsen, Donna M.;Volberding, Paul A.
通讯作者：
Volberding, Paul A.
影响因子：
2.4
作者：
Sav, Adem;Kendall, Elizabeth;Wheeler, Amanda J.
通讯作者：
Wheeler, Amanda J.
影响因子：
--
作者：
Fields-Gardner, Cade;Campa, Adriana
通讯作者：
Campa, Adriana
影响因子：
4.4
作者：
Quinn, Katherine;Voisin, Dexter R.;Schneider, John
通讯作者：
Schneider, John
影响因子：
3.6
作者：
Sav, Adem;Whitty, Jennifer A.;Wheeler, Amanda J.
通讯作者：
Wheeler, Amanda J.