Effects of resveratrol treatment on bone and cartilage in obese diabetic mice.
Effects of resveratrol treatment on bone and cartilage in obese diabetic mice.
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DOI：
10.1186/s40200-015-0141-6
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发表时间：
2015
影响因子：
2.8
通讯作者：
Plochocki JH
中科院分区：
文献类型：
--
作者：
Cooley J;Broderick TL;Al-Nakkash L;Plochocki JH
白藜芦醇是一种多酚类植物抗毒素，已被证明具有骨保护和软骨保护特性。我们研究了白藜芦醇治疗对肥胖、糖尿病ob/ob小鼠骨和软骨组织的影响。8周龄的ob/ob和瘦对照小鼠口服25 mg/kg的反式白藜芦醇，持续3周。组织形态学和横截面几何变量进行了分析。肥胖/肥胖小鼠股骨长度、抗负荷能力、胫骨生长板总面积和钙化面积均显著低于瘦对照组（P < 0.05）。白藜芦醇治疗显着增加皮质面积在肥胖症/肥胖症和对照组小鼠，但没有改善抗弯曲的横截面指标。白藜芦醇治疗组小鼠胫骨长度和钙化生长板软骨面积也较未治疗组减少（P < 0.05）。白藜芦醇治疗ob/ob小鼠对股骨中段的骨组织形态计量学有不同的影响。治疗增加了皮质面积，但降低了骨长度。
Resveratrol is a polyphenolic phytoalexin that has been shown to exhibit osteoprotective and chondroprotective properties. We examine the effects of resveratrol treatment on bone and cartilage tissue of obese, diabetic ob/ob mice. Eight-week-old ob/ob and lean control mice were given trans-resveratrol at an oral dose of 25 mg/kg for 3 weeks. Histomorphometric and cross-sectional-geometric variables were analyzed. Ob/ob mice in our study exhibit significantly reduced femoral length, resistance to loading, and tibial growth plate total area and calcified area than lean controls (P < 0.05). Resveratrol treatment significantly increased cortical area in both ob/ob and control mice, but did not improve cross-sectional indicators of resistance to bending. Resveratrol treatment also reduced tibial length and calcified growth plate cartilage area in comparison to untreated mice (P < 0.05). Resveratrol treatment of ob/ob mice had mixed effects on bone histomorphometry at the femoral midshaft. Treatment increased cortical area but decreased bone length.
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影响因子：
4.1
作者：
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通讯作者：
Myoui, A
DOI：
10.1016/j.bbrc.2010.09.053
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通讯作者：
de Cabo R