Opposing roles for D-1 and D-2 dopamine receptors in efflux of cyclic AMP from rat neostriatum
Opposing roles for D-1 and D-2 dopamine receptors in efflux of cyclic AMP from rat neostriatum
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DOI：
10.1038/294366a0
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发表时间：
1981-11-01
期刊：
影响因子：
64.8
通讯作者：
Kebabian, J. W.
中科院分区：
文献类型：
--
作者：
Stoof, J. C.;Kebabian, J. W.
现在已经确定了两种类型的多巴胺受体，它们的刺激作用会影响细胞内的环磷酸腺苷。在昆虫神经节和哺乳动物新纹状体等不同的组织中，刺激名为D-1的多巴胺受体会增加环状AMP(1-6)的形成，而刺激第二种类型的多巴胺受体(D-2)(7-11)会减少环状AMP的形成。最近，在大鼠新纹状体中也发现了一种具有D-2受体药理特性的受体(12-14)；我们在这里表明，刺激该受体之后，用D-1激动剂刺激V诱导的环磷酸腺苷的形成减少。
Two types of dopamine receptor whose stimulation affects cellular cyclic AMP have now been identified. In tissues as different as insect ganglia and mammalian neostriatum, stimulation of the dopamine receptor called D-1 increases formation of cyclic AMP(1-6), whereas stimulation of the second type of dopamine receptor (D-2)(7-11), first identified in the rat pituitary gland, reduces cyclic AMP formation. Recently, a receptor with the pharmacological properties of the D-2 receptor has also been found(12-14) in the rat neostriatum; we show here that stimulation of this receptor is followed by a reduction in cyclic AMP formation induced by V stimulation with D-1 agonists.