Selective anergy of V beta 8+,CD4+ T cells in Staphylococcus enterotoxin B-primed mice.
Selective anergy of V beta 8+,CD4+ T cells in Staphylococcus enterotoxin B-primed mice.
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DOI：
10.1084/jem.172.4.1065
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发表时间：
1990-10-01
影响因子：
15.3
通讯作者：
Ochi, A
中科院分区：
文献类型：
--
作者：
Kawabe, Y;Ochi, A
已经研究了体外和体内 T 细胞对葡萄球菌肠毒素 B (SEB) 反应的细胞基础。在SEB体外反应中观察Vβ8.1、2+、CD4+和CD8+T细胞的增殖和细胞毒性。在初级细胞毒性测定中，来自对照脾脏的 CD4+ T 细胞比其 CD8+ 对应物更活跃，然而，在来自 SEB 引发的小鼠的细胞中，CD8+ T 细胞在 SEB 特异性细胞毒性中占主导地位。体内 SEB 引发消除了 V beta 8.1,2+,CD4+ T 细胞的反应，尽管这些细胞存在大量。这种 SEB 特异性无反应性仅发生在 V beta 8.1,2+,CD4+ T 细胞中，而不发生在 CD8+ T 细胞中。这些发现表明，在胸腺后耐受中，CD4+ 和 CD8+ T 细胞对诱导抗原特异性无反应性的要求是不同的，并且表明存在诱导 T 细胞无反应性的共能信号。
The cellular basis of the in vitro and in vivo T cell responses to Staphylococcus enterotoxin B (SEB) has been investigated. The proliferation and cytotoxicity of V beta 8.1,2+,CD4+ and CD8+ T cells were observed in in vitro response to SEB. In primary cytotoxicity assays, CD4+ T cells from control spleens were more active than their CD8+ counterparts, however, in cells derived from SEB-primed mice, CD8+ T cells were dominant in SEB-specific cytotoxicity. In vivo priming with SEB abrogated the response of V beta 8.1,2+,CD4+ T cells despite the fact that these cells exist in significant number. This SEB- specific anergy occurred only in V beta 8.1,2+,CD4+ T cells but not in CD8+ T cells. These findings indicate that the requirement for the induction of antigen-specific anergy is different between CD4+ and CD8+ T cells in post-thymic tolerance, and the existence of coanergic signals for the induction of T cell anergy is suggested.