Zero-order controlled-release polymer matrices for micro- and macromolecules.
Zero-order controlled-release polymer matrices for micro- and macromolecules.
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DOI：
10.1002/jps.2600720105
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发表时间：
1983
影响因子：
3.8
通讯作者：
D. Hsieh;W. Rhine;R. Langer
中科院分区：
文献类型：
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作者：
D. Hsieh;W. Rhine;R. Langer
理论和实验分析表明，半球形聚合物-药物基质层合一层不透水涂层，除了在中心表面有一个暴露腔，可以用来实现零级释放动力学。通过在黄铜模具中加热和压缩聚乙烯和药物（水杨酸钠）制备了低分子量药物的半球系统。高分子量药物的半球形体系是通过在-80度的半球形模具中浇铸乙烯-醋酸乙烯共聚物和蛋白质，然后进行两步干燥程序（-20和20度）制备的。在这两种系统中，在半球的中心表面制造空腔，其余的基质涂上一层不渗透的材料。从含有牛血清白蛋白（摩尔重量68,000）的聚合物基质中，以0.5 mg/天的速率实现了60天的零级释放。
Theoretical and experimental analyses demonstrate that a hemispheric polymer-drug matrix laminated with an impermeable coating, except for an exposed cavity in the center face, can be used to achieve zero-order release kinetics. Hemispheric systems for low molecular weight drugs were prepared by heating and compressing polyethylene and drug (sodium salicylate) in a brass mold. Hemispheric systems for high molecular weight drugs were prepared by casting ethylene-vinyl acetate copolymer and protein in a hemispheric mold at -80 degrees, followed by a two-step drying procedure (-20 and 20 degrees). In both systems, cavities were made in the center face of the hemispheres and the remainder of the matrices coated with an impermeable material. Zero-order release for 60 days at a rate of 0.5 mg/day was achieved from polymer matrices containing bovine serum albumin (mol. wt. 68,000).