Endogenous toll-like receptor ligands and their biological significance.
Endogenous toll-like receptor ligands and their biological significance.
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内源性Toll样受体配体及其生物学意义。
DOI：
10.1111/j.1582-4934.2010.01127.x
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发表时间：
2010-11
影响因子：
5.3
通讯作者：
Chen S
中科院分区：
文献类型：
--
作者：
Yu L;Wang L;Chen S
Toll样受体是一类模式识别受体家族，识别和应答微生物的保守成分，在天然免疫和获得性免疫中发挥重要作用。除了与病原体来源的外源性配体结合外，TLRs还与受损组织或死亡细胞释放的内源性分子相互作用，调节许多无菌炎症过程。推测的内源性TLR配体包括蛋白质和多肽、多糖和蛋白多糖、核酸和磷脂，它们是细胞成分，特别是细胞外基质降解产物。越来越多的证据表明，内源性配体介导的TLR信号参与了组织损伤、修复和再生、自身免疫性疾病和肿瘤发生等病理状态。TLRs识别内源性刺激因子的能力似乎对其调节非感染性炎症的功能至关重要。在这篇综述中，我们总结了内源性TLR配体的研究现状，并讨论了内源性配体在几种无菌炎症条件下触发TLR信号转导的生物学意义。
Toll-like receptors (TLRs), a family of pattern recognition receptors, recognize and respond to conserved components of microbes and play a crucial role in both innate and adaptive immunity. In addition to binding exogenous ligands derived from pathogens, TLRs interact with endogenous molecules released from damaged tissues or dead cells and regulate many sterile inflammation processes. Putative endogenous TLR ligands include proteins and peptides, polysaccharides and proteoglycan, nucleic acids and phospholipids, which are cellular components, particularly extracellular matrix degradation products. Accumulating evidence demonstrates that endogenous ligand-mediated TLR signalling is involved in pathological conditions such as tissue injury, repair and regeneration; autoimmune diseases and tumorigenesis. The ability of TLRs to recognize endogenous stimulators appears to be essential to their function in regulating non-infectious inflammation. In this review, we summarize current knowledge of endogenous TLR ligands and discuss the biological significance of TLR signalling triggered by endogenous ligands in several sterile inflammation conditions.
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