Four spiroquinazoline alkaloids from Eupenicillium sp isolated as an endophytic fungus from leaves of Murraya paniculata (Rutaceae)
Four spiroquinazoline alkaloids from Eupenicillium sp isolated as an endophytic fungus from leaves of Murraya paniculata (Rutaceae)
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DOI：
10.1016/j.bse.2004.09.002
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发表时间：
2005-03-01
影响因子：
1.6
通讯作者：
Rodrigues, E
中科院分区：
文献类型：
--
作者：
Barros, FAP;Rodrigues, E
真青霉属 (Eupenicillium spp.)是从表面灭菌后的九里香（芸香科）健康叶子中分离出来的。这种真菌在灭菌的白玉米中培养，产生螺喹唑啉生物碱阿兰替平酮、阿兰曲苯酮、阿兰曲蒎烯和阿兰曲亮酮。用甲醇提取培养物并通过硅胶色谱和HPLC的组合分离生物碱。通过广泛的光谱研究（包括 2D NMR 和 MS-MS 实验）阐明了这些结构。讨论了内生菌在植物次生代谢物生物合成中的可能作用。 (C) 2005 Elsevier Ltd. 保留所有权利。
A Eupenicillium spp. was isolated from healthy leaves of Murraya paniculata (Rutaceae) after surface sterilization. This fungus was cultivated in sterilized white-corn, where the spiroquinazoline alkaloids alanditrypinone, alantryphenone, alantrypinene and alantryleunone were produced. The culture was extracted with methanol and the alkaloids were isolated by a combination of silica gel chromatography and HPLC. The structures were elucidated by extensive spectroscopic studies, including 2D NMR and MS-MS experiments. The possible role of endophytes in the biosynthesis of plant secondary metabolites is discussed. (C) 2005 Elsevier Ltd. All rights reserved.