Oxidation-reduction sensitive interaction of a cellular 50-kDa protein with an RNA hairpin in the 5' noncoding region of the poliovirus genome.
Oxidation-reduction sensitive interaction of a cellular 50-kDa protein with an RNA hairpin in the 5' noncoding region of the poliovirus genome.
复制标题
细胞 50 kDa 蛋白与脊髓灰质炎病毒基因组 5 非编码区 RNA 发夹的氧化还原敏感相互作用。
DOI：
10.1073/pnas.87.15.5846
复制
发表时间：
1990
影响因子：
11.1
通讯作者：
Sarnow,P
中科院分区：
文献类型：
--
作者：
Najita,L;Sarnow,P
Genetic and biochemical analyses of the 5' noncoding region of poliovirus have indicated the importance of this region in both translation and amplification of the viral RNA. The role of the cellular machinery required for these events is just beginning to be revealed. Using an RNA gel retention assay, we have identified a cellular 50-kDa protein that forms a specific complex with a stable stem-loop structure present in the viral 5' noncoding region. The formation of the RNA-protein complex is dependent on the availability of free sulfhydryl groups in the protein. The possible involvement of this RNA-protein complex in the regulation of viral gene expression is discussed.
