Animal Models of Diabetic Neuropathic Pain
Animal Models of Diabetic Neuropathic Pain
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DOI：
10.1007/978-1-60761-880-5_9
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发表时间：
2011-01-01
期刊：
影响因子：
--
通讯作者：
Stimers, Joseph R.
中科院分区：
文献类型：
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作者：
Dobretsov, Maxim;Backonja, Miroslav (Misha);Stimers, Joseph R.
疼痛通常是糖尿病患者远端周围神经病变 (DPN) 最早且最成问题的综合征。疼痛性 DPN 的发病时间、持续时间和进展、方式以及个体表现的严重程度各不相同，使得糖尿病神经病变患者疼痛机制的分类和评估成为一项极其困难的任务。解决这一问题的一个关键步骤是需要进行大规模前瞻性研究，从无痛糖尿病前期或糖尿病受试者开始，并使用标准化的问卷和神经床边和定量感觉测试来评估所有可能的疼痛方式和类型的进展。然而，就其本质而言，即使是最装备和设计最好的临床研究也大多是观察性的，如果不进行动物模型研究，就不可能深入了解人类疾病。在过去的几十年中，已经开发并表征了多种糖尿病啮齿动物模型。 DPN 在许多模型中的进展也已得到研究和证实，在这项工作中，我们回顾了这些数据，特别关注在糖尿病疼痛机制研究中使用啮齿动物模型的效用、挑战和局限性。
Pain is frequently the earliest and most problematic syndrome of distal peripheral neuropathy (DPN) in diabetic patients. The variety of time of onset, duration and progression, modalities, and severity of individual presentations of painful DPN makes classification and evaluation of mechanisms of pain in patients with diabetic neuropathy an outstandingly difficult task. One critical step to address this issue is the need for large-scale prospective studies that start in pain-free prediabetic or diabetic subjects and use questionnaires and neurological bedside and quantitative sensory tests standardized to assess progression of all possible modalities and types of pain. By their nature, however, even the best equipped and designed clinical studies remain mostly observational, and in-depth understanding of human disease is not possible without studies in animal models. Over the past several decades, a wide variety of rodent models of diabetes have been developed and characterized. Progression of DPN in many of these models has also been studied and confirmed, and in this work, we review those data with a specific focus on the utility, challenges, and limitations of using rodent models in research on mechanisms of diabetic pain.