Tolerance to continuous intrathecal baclofen infusion can be reversed by pulsatile bolus infusion
Tolerance to continuous intrathecal baclofen infusion can be reversed by pulsatile bolus infusion
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DOI：
10.1038/sc.2009.156
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发表时间：
2010-06-01
期刊：
影响因子：
2.2
通讯作者：
van Laar, T.
中科院分区：
文献类型：
--
作者：
Heetla, H. W.;Staal, M. J.;van Laar, T.
研究设计：目的：研究鞘内巴氯芬（ITB）脉冲推注对ITB日剂量的影响，患者显示剂量增加，可能是由于耐受性。从4例从ITB连续输注转换为脉冲推注的患者中收集剂量和临床疗效数据，结果：从连续输注改为脉冲推注后，每日ITB剂量减少，而临床疗效保持稳定，未发生不良事件。结论：ITB脉冲式推注似乎是一种有效且安全的治疗策略，可逆转可能诊断为ITB耐受的患者对增加ITB剂量的需求。Spinal Cord（2010）48，483-486; doi：10.1038/sc.2009.156; 2009年11月17日在线发表
Study design: Pilot study.Objective: To study the effect of pulsatile bolus infusion of intrathecal baclofen (ITB) on daily ITB dose, in patients showing dose increases, probably due to tolerance.Setting: Department of neurology and neurosurgery, University Medical Center Groningen, the Netherlands.Methods: Data on dosages and clinical efficacy were gathered from four patients who were switched from continuous to pulsatile bolus infusion of ITB, because of the probable diagnosis of tolerance to ITB.Results: Switching from continuous to pulsatile bolus infusion resulted in a decrease of the daily ITB dose, while the clinical effect could be kept stable, without introducing adverse events.Conclusion: Pulsatile bolus infusion of ITB seems to be an effective and safe treatment strategy to reverse the need for increasing ITB dosages in patients with the probable diagnosis of tolerance to ITB. Spinal Cord (2010) 48, 483-486; doi: 10.1038/sc.2009.156; published online 17 November 2009