IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
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DOI：
10.1126/science.278.5343.1612
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发表时间：
1997-11-28
期刊：
影响因子：
56.9
通讯作者：
Dixit, VM
中科院分区：
文献类型：
--
作者：
Muzio, M;Ni, J;Dixit, VM
The interleukin-1 receptor (IL-1R) signaling pathway leads to nuclear factor kappa B (NF-kappa B) activation in mammals and is similar to the Toll pathway in Drosophila: the IL-1R-associated kinase (IRAK) is homologous to Pelle. Two additional proximal mediators were identified that are required for IL-1R-induced NF-kappa B activation: IRAK-2, a Pelle family member, and MyD88, a death domain-containing adapter molecule. Both associate with the IL-IR signaling complex. Dominant negative forms of either attenuate IL-1R-mediated NF-kappa B activation. Therefore, IRAK-2 and MyD88 may provide additional therapeutic targets for inhibiting IL-1-induced inflammation.
