The Copenhagen Prospective Study on Asthma in Childhood (COPSAC): design, rationale, and baseline data from a longitudinal birth cohort study
The Copenhagen Prospective Study on Asthma in Childhood (COPSAC): design, rationale, and baseline data from a longitudinal birth cohort study
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DOI：
10.1016/s1081-1206(10)61398-1
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发表时间：
2004-10-01
影响因子：
5.9
通讯作者：
Bisgaard, H
中科院分区：
文献类型：
--
作者：
Bisgaard, H
背景资料：特应性疾病哮喘、特应性皮炎和过敏性鼻炎是儿童中最常见的慢性疾病，并且它们的患病率最近在工业化国家有所增加。鲜为人知的是驱动这种proliferation.Objective的遗传-环境相互作用因素：探讨遗传，环境和生活方式因素之间的关系，在发展中的特应性疾病的高危儿童，以证据为基础的预防strategy.Methods的目的：哥本哈根前瞻性研究哮喘在儿童是一个单中心，出生队列研究哮喘母亲的孩子。客观评估从出生时开始，每6个月进行一次定期访视，并在出现急性症状时进行。临床结果包括哮喘前期、哮喘、特应性皮炎、过敏性鼻炎、过敏、肺功能和支气管反应性。暴露评估包括呼吸道、肠道和皮肤微生物学;儿童的饮食;室内和室外空气质量;过敏原;以及生活方式指标。先证者和父母的遗传特征进行了评估。质量保证遵循良好的临床实践guidelines.Results：四百十一名哮喘母亲的婴儿在一个月的年龄入组。这些孩子出生于1998年8月2日至2001年12月28日之间。与哥本哈根人口相比，队列人口的母亲不太可能自然分娩。这些家庭稍微不那么富裕，孩子和宠物都比较少。白人可能被过度代表。在2岁时，93%的婴儿仍然积极参与cohol.Conclusions：这纵向出生队列研究的高风险丹麦婴儿的客观表型，详细的信息曝光，高数据质量，和高参与者留存率。
Background: The atopic diseases asthma, atopic dermatitis, and allergic rhinitis are the most common chronic diseases in children, and their prevalence has increased recently in industrialized nations. Little is known about the genetic-environmental interaction factors driving such proliferation.Objective: To investigate the relationships among genetic, environmental, and lifestyle factors in the development of atopic diseases in high-risk children with the aim of developing evidence-based prevention strategies.Methods: The Copenhagen Prospective Study on Asthma in Childhood is a single-center, birth cohort study of children of asthmatic mothers. Objective assessments begin at birth, with scheduled visits every 6 months and when acute symptoms manifest. Clinical outcomes comprise preasthma, asthma, atopic dermatitis, allergic rhinitis, allergy, lung function, and bronchial responsiveness. Exposure assessments comprise respiratory, intestinal, and skin microbiology; the child's diet; indoor and outdoor air quality; allergens; and indicators of lifestyle. Genetic characteristics of probands and parents are evaluated. Quality assurance follows Good Clinical Practice guidelines.Results: Four hundred eleven infants of asthmatic mothers were enrolled at the age of I month. The children were born between August 2, 1998, and December 28, 2001. Compared with the Copenhagen population, mothers of the cohort population were less likely to have given natural childbirth. The households were slightly less affluent, with fewer children and fewer pets. Whites may be overrepresented. At age 2 years, 93% of the infants were still actively participating in the cohort.Conclusions: This longitudinal birth cohort study of high-risk Danish infants consists of objective phenotyping, detailed information on exposure, high data quality, and a high participant retention rate.