Silk fibroin supraparticles created by the evaporation of colloidal Ouzo droplets
Silk fibroin supraparticles created by the evaporation of colloidal Ouzo droplets
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DOI：
10.1063/5.0057228
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发表时间：
2021-08-01
期刊：
影响因子：
1.6
通讯作者：
Zhao, Hui
中科院分区：
文献类型：
--
作者：
Lamb, Ashley;He, Fengjie;Zhao, Hui
由于其高的生物相容性和生物降解性，由家蚕（B. mori）茧-可以在生物医学领域找到各种应用。通过不需要能量也不需要表面活性剂来蒸发Ouzo液滴是一种环境友好、简单且具有成本效益的制造三维超颗粒的策略，解决了与液滴蒸发相关的所谓“咖啡环效应”。将丝素蛋白溶解成由超纯水、乙醇、反式茴香脑油和甲酸组成的四元液滴。Ouzo液滴能够形成油环，促进液滴收缩以产生三维超颗粒。使用Ouzo效应从丝素蛋白制造这些颗粒导致具有高孔隙率的一致的大孔结构。
Due to its high biocompatibility and biodegradability, supraparticles made from silk fibroin-produced from Bombyx mori (B. mori) cocoons-can find various applications in biomedical fields. The evaporation of Ouzo droplets by not requiring energy nor a surfactant is an environmentally friendly, easy, and cost-effective strategy to fabricate three-dimensional supraparticles, tackling the so-called "coffee ring effect" associated with droplet evaporation. Silk fibroins are dissolved into quaternary droplets, comprised of ultrapure water, ethanol, trans-anethole oil, and formic acid. The Ouzo droplet is able to form an oil ring that facilitates the droplet contraction to create a three-dimensional supraparticle. Using the Ouzo effect to fabricate these particles from silk fibroin results in consistent macro-porous structures with a high porosity.