Resident cells of the myocardium: more than spectators in cardiac injury, repair and regeneration.
Resident cells of the myocardium: more than spectators in cardiac injury, repair and regeneration.
复制标题
DOI：
10.1016/j.cophys.2017.08.001
复制
发表时间：
2018-03
影响因子：
2.5
通讯作者：
Meloni M
中科院分区：
文献类型：
--
作者：
Gray GA;Toor IS;Castellan R;Crisan M;Meloni M
成人心脏中大多数新的心肌细胞和内皮细胞都是细胞周期重新进入的。细胞外基质是调节心脏细胞行为的分子的关键来源。成纤维细胞在吞噬凋亡细胞后改变其表型以解决炎症。多种常驻细胞类型有助于在生命过程中维持心脏的结构和生理功能。心肌细胞增殖支持新生儿心脏损伤后的无疤痕再生，但成人心脏的增殖率较低，需要用胶原疤痕替代以维持心室完整性。在这篇简短的综述中，我们讨论了最近的研究，这些研究确定了非心肌细胞驻留细胞和细胞外基质在心肌梗死后支持修复以及心肌细胞和血管再生中的新作用。
Cell cycle re-entry accounts for most new cardiomyocytes and endothelial cells in the adult heart. The extracellular matrix is a key source of molecules that regulate heart cell behaviour. Fibroblasts change their phenotype to resolve inflammation after phagocytosing apoptotic cells. Multiple resident cell types contribute to maintaining the structure and physiological function of the heart over the life course. Cardiomyocyte proliferation supports scar free regeneration in the neonatal heart following injury, but a lower rate of proliferation in the adult necessitates replacement by a collagen scar to maintain ventricular integrity. In this short review we discuss recent studies that have identified novel roles for non-myocyte resident cells and the extracellular matrix in supporting repair, as well as cardiomyocyte and vascular regeneration, following myocardial infarction.