HHV-8-associated T-cell lymphoma in a lymph node with concurrent peritoneal effusion in an HIV-positive man
HHV-8-associated T-cell lymphoma in a lymph node with concurrent peritoneal effusion in an HIV-positive man
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DOI：
10.1097/01.pas.0000157937.01624.1d
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发表时间：
2005-05-01
影响因子：
5.6
通讯作者：
Stein, H
中科院分区：
文献类型：
--
作者：
Coupland, SE;Charlotte, F;Stein, H
原发性积液性淋巴瘤是一种罕见的大细胞淋巴瘤，常见于人类免疫缺陷病毒（HIV）感染患者。PEL具有多种临床、组织形态学和免疫表型特征，并与人类疱疹病毒8 （HHV-8）相关。PEL可能表现为体腔淋巴瘤积液或实体瘤肿块。大多数所谓的“实性PEE”通常位于结外；极少发生在淋巴结。PEL主要由b细胞基因型的恶性细胞组成；很少是由t细胞引起的。我们报告一例罕见的hhv -8相关的t细胞型“实体PEL”，患者为41岁的hiv血清阳性男性，伴有腹膜积液。t细胞淋巴瘤的诊断是基于形态学、免疫表型和淋巴结活检的分子结果。肿瘤细胞强烈表达CD45R0、CD7、CD43、MUM1/IRF4、CD30、HHV-8和EBER，并表现出t细胞受体γ链基因的克隆重排。以下病例提供了另一个淋巴结为基础的“实性”PEL，显示了hhv -8相关淋巴瘤谱内的多样性。
Primary effusion lymphoma (PEL) is an uncommon large cell lymphoma, usually seen in human immunodeficiency virus (HIV)-infected patients. PEL is characterized by various clinical, histomorphologic, and immunophenotypical features, and is associated with the human herpes virus 8 (HHV-8). PEL may present as either a body cavity-based lymphomatous effusion or a solid tumor mass. Most so-called "solid PEE" usually have an extranodal location; exceptionally rarely, they occur in lymph nodes. The majority of PEL consist of malignant cells of B-cell genotype; seldom they are of T-cell origin. We report a rare case of HHV-8-associated "solid PEL'' of T-cell type in a 41-year-old HIV-seropositive man with a concomitant peritoneal effusion. The T-cell lymphoma was diagnosed on the basis of morphologic, immunophenotypic, and molecular findings of a lymph node biopsy. The tumor cells strongly expressed CD45R0, CD7, CD43, MUM1/IRF4, CD30, HHV-8, and EBER, and demonstrated a clonal rearrangement of T-cell receptor-gamma chain gene. The following case provides another example of a lymph node-based "solid" PEL, demonstrating the variety within the spectrum of HHV-8-associated lymphoma.