THE STRUCTURE AND FUNCTION OF TRANSFER-RNA GENES OF HIGHER EUKARYOTES
THE STRUCTURE AND FUNCTION OF TRANSFER-RNA GENES OF HIGHER EUKARYOTES
复制标题
DOI：
10.1007/bf01965537
复制
发表时间：
1981-01-01
期刊：
影响因子：
--
通讯作者：
KUBLI, E
中科院分区：
文献类型：
--
作者：
KUBLI, E
最新的研究结果有关的结构和功能的高等真核生物的tRNA基因进行了讨论，在一个典型的方式。高等生物的tRNA基因分散或聚集在基因组的不同位点。簇包含在两个方向上取向的tRNA基因，并且在DNA的两条链上，其间具有不同长度的间隔区。一些基因在反密码子的3′端附近含有插入序列。初级转录产物具有一个5′前导序列和一个3′尾随序列，它们在严格的时间和空间顺序中通过几个成熟步骤被去除。内部转录控制区（启动子）位于tRNA基因成熟tRNA编码区的5′端和3′端。调节表达效率的外部序列存在于基因的5′端。转移RNA基因非随机地位于核小体中。
The most recent findings concerning the structure and function of tRNA genes of higher eukaryotes are discussed in an exemplary way. The tRNA genes of higher organisms are either dispersed or clustered at different sites of the genome. Clusters contain tRNA genes oriented in both directions and on both strands of the DNA with spacers of various length inbetween. Some genes contain intervening sequences close to the 3′ side of the anticodon. The primary transcription product possesses a 5′ leader and a 3′ trailer sequence which are removed by several maturation steps in a strict temporal and spacial order. Internal transcription control regions (promotors) are located at the 5′ and 3′ ends of the mature tRNA coding section of the tRNA gene. External sequences modulating the efficiency of the expression are present at the immediate 5′ ends of the genes. Transfer RNA genes are located nonrandomly in the nucleosomes.