Influence of Anabolic Steroid on Tibial Fracture Healing in Rabbits - A Study on Experimental Model
Influence of Anabolic Steroid on Tibial Fracture Healing in Rabbits - A Study on Experimental Model
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DOI：
10.7860/jcdr/2012/4863.2679
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发表时间：
2013-01-01
影响因子：
0.2
通讯作者：
Faruqi, N. A.
中科院分区：
文献类型：
--
作者：
Ahmad, Farida;Yunus, Syed Mobashir;Faruqi, N. A.
简介：合成代谢类固醇是一种治疗分解代谢状态的既定药物。所述药物已被证明可以恢复瘦体重，防止骨质疏松症和纠正受损的免疫反应，但只有少数研究评价了相同的骨折愈合的效果。方法：骨折由一个冲击装置在24只兔子，分为实验组（I）和对照组（11），每组12只动物。结果与结论：癸酸诺龙10 mg/kg肌肉注射，每周2次，连续2周和4周，治疗组骨折愈合时间较对照组明显延长，骨折愈合后第15天和第40天的X线片显示，癸酸诺龙10 mg/kg肌肉注射组骨折愈合时间较对照组明显延长，骨折愈合后第15天和第40天的X线片显示，癸酸诺龙1第15天和第40天的骨痂组织化学检查和高血清碱性磷酸酶水平证实了实验动物的矿化效果更好。
Introduction: Anabolic steroid is an established drug for treating catabolic states. The said drug has been shown to restore the lean body mass, to prevent osteoporosis and to correct the impaired immune response, but only few studies have evaluated the effect of the same on fracture healing.Methods: Fracture was produced by an impact device in 24 rabbits which were divided into experimental (I) and control (11) groups of 12 animals each. The experimental groups were further divided into the subgroups IA and IB of equal animals, which received Nandrolone Decanoate 10 mg/kg intramuscularly, biweekly for 2 weeks and 4 weeks respectively.Results and Conclusion: Radiographs taken on the post fracture day15 and 40 showed better healing in the Nandrolone Decanoate administrated groups as a dense periosteal bone formation and prevention of the local osteoporosis. Histochemical examination of the callus and high serum alkaline phosphatase levels on day 15 and 40 confirmed better mineralization in experimental animals.