Low-Cost Fetal Magnetocardiography: A Comparison of Superconducting Quantum Interference Device and Optically Pumped Magnetometers
Low-Cost Fetal Magnetocardiography: A Comparison of Superconducting Quantum Interference Device and Optically Pumped Magnetometers
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DOI：
10.1161/jaha.119.013436
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发表时间：
2019-08-20
影响因子：
5.4
通讯作者：
Wakai, Ronald T.
中科院分区：
文献类型：
--
作者：
Strand, Sarah;Lutter, William;Wakai, Ronald T.
背景-胎儿心磁图(FMCG)是一种评估患有危及生命的心律失常的胎儿的高效技术，但其推广受到了超导量子干涉装置(SQUID)仪器的高成本和复杂性的限制。光泵磁强计(OPM)是一种很有前途的新技术，可以在许多应用中取代SQUID。这项研究比较了使用OPMS在个人大小的磁屏蔽室中操作的FMCG系统的性能，以及使用在磁屏蔽室中操作的SQUID磁力计的传统FMCG系统的性能。方法和结果-24名受试者使用SQUID系统进行FMCG记录，母亲仰卧在磁屏蔽室中，而OPM系统的母亲俯卧在个人大小的圆柱形屏蔽室中。OPM和SQUID记录的信噪比在统计上没有差异，足以用于两种技术的诊断目的。虽然使用小型开放式屏蔽罩的环境噪声较高，但俯卧位获得的较高信号幅度抵消了这一影响，从而缩短了胎儿与传感器之间的距离，并改善了患者的舒适感。在几个受试者中，FMCG提供了比单独使用超声心动图更准确和/或明确的鉴别诊断。结论-基于OPM的系统是便携式的，改善了患者的舒适度，并且以一小部分成本与基于SQUID的系统一样好。对胎儿节律的电生理评估现在是实用的，并将对患有长QT综合征和其他危及生命的心律失常的胎儿的治疗产生重大影响。
Background-Fetal magnetocardiography (fMCG) is a highly effective technique for evaluation of fetuses with life-threatening arrhythmia, but its dissemination has been constrained by the high cost and complexity of Superconducting Quantum Interference Device (SQUID) instrumentation. Optically pumped magnetometers (OPMs) are a promising new technology that can replace SQUIDs for many applications. This study compares the performance of an fMCG system, utilizing OPMs operating in a person-sized magnetic shield, to that of a conventional fMCG system, utilizing SQUID magnetometers operating in a magnetically shielded room.Methods and Results-fMCG recordings were made in 24 subjects using the SQUID system with the mother lying supine in a magnetically shielded room and the OPM system with the mother lying prone in a person-sized, cylindrical shield. Signal-to-noise ratios of the OPM and SQUID recordings were not statistically different and were adequate for diagnostic purposes with both technologies. Although the environmental noise was higher using the small open-ended shield, this was offset by the higher signal amplitude achieved with prone positioning, which reduced the distance between the fetus and sensors and improved patient comfort. In several subjects, fMCG provided a differential diagnosis that was more precise and/or definitive than was possible with echocardiography alone.Conclusions-The OPM-based system was portable, improved patient comfort, and performed as well as the SQUID-based system at a small fraction of the cost. Electrophysiological assessment of fetal rhythm is now practical and will have a major impact on management of fetuses with long QT syndrome and other life-threatening arrhythmias.