Lateral prefrontal damage affects processing selection but not attention switching
Lateral prefrontal damage affects processing selection but not attention switching
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DOI：
10.1016/s0926-6410(01)00132-x
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发表时间：
2002-04-01
期刊：
影响因子：
--
通讯作者：
Knight, RT
中科院分区：
文献类型：
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作者：
Gehring, WJ;Knight, RT
认知神经科学面临的一个挑战是确定前额叶皮质(PFC)如何参与监督思想和行动的认知控制操作。我们研究了在两种注意控制方式下，损伤对外侧PFC的影响。受试者完成一项需要注意转换和加工选择的选择反应时任务。将患有PFC或顶叶皮质损害的个体与年龄匹配的年轻对照组的表现进行比较。外侧PFC的损伤并没有显著损害从注意一种颜色到注意另一种颜色的切换。然而，损毁PFC确实显著增加了分心物刺激的影响，暗示侧向PFC参与了加工选择。个别受试者的表现表明，左下后PFC对加工选择是最关键的。我们的数据与这样的观点是一致的，即外侧PFC有助于自上而下地控制从感觉输入到运动输出的通路上的信息流。(C)2002 Elsevier Science B.V.保留所有权利。
A challenge for cognitive neuroscience is to determine how the prefrontal cortex (PFC) contributes to the cognitive control operations that oversee thought and action. We studied the effects of damage to the lateral PFC in two types of attentional control. Subjects performed a choice reaction time task that required attention switching and processing selection. The performance of individuals with PFC or parietal cortex damage was compared with that of age-matched and young control subjects. Damage to the lateral PFC did not significantly impair the switch from attending to one color to attending to another. PFC damage did, however, significantly increase the effects of distractor stimuli, implicating the lateral PFC in processing selection. Individual subjects' performance suggested that the left inferior posterior PFC was the most critical for processing selection. Our data are consistent with the view that the lateral PFC contributes to the top-down control of the information flow along pathways from sensory input to motor output. (C) 2002 Elsevier Science B.V. All rights reserved.